rhizomes

The biological activity of Jervine (Jerwiny) is mediated via its interaction with the 7 passes transmembrane protein Smoothened. Jervine binds with and inhibits smoothened, which is an integral part of the Hedgehog signaling pathways. With smoothened inhibited, the GLI1 transcription cannot be activated and Hedgehog target genes cannot be transcribed.

17-Hydroxy sprengerinin C is a glycoside compound isolated from rhizomes of Polygonatum sibiricum with stronger anticancer activities. 17-Hydroxy sprengerinin C reduces the expression of Blc-2 and pro-caspase3 and increases the production of Bax.

Zerumbone is a natural monocyclic sesquiterpene first isolated from rhizomes of the wild ginger Z. zerumbet.It has also been shown to have anti-oxidant and anti-inflammatory activities, contributing to immunomodulatory and hepatoprotective effects.

(E)-3,4,5-Trimethoxycinnamic acid (O-Methylsinapic acid) is a natural compound derived from the roots and rhizomes of Notopterygium incisum.

Thymol methyl ether (2-methoxy-4-methyl-1-(propan-2-yl)benzene) is a volatile substance present in the rhizomes of Arnica officinalis with potential antibacterial and anticancer antioxidant activity.

7-O-MethylMangiferin is an xanthone isolated from the rhizomes of Iris nigricans.

Dichotomitin is an natural isoflavonoid isolated from the rhizomes of Belamcanda chinensis (L.) DC.

ar-Turmerone is a natural volatile organic compound extracted from the rhizomes of turmeric (Curcuma longa). ar-Turmerone exhibits oral bioavailability and possesses biological activities such as antitumor, anti-inflammatory, antioxidant, and neuroprotective effects. ar-Turmerone exerts a positive regulatory effect on dendritic cells in mice. Ar-turmerone can induce neural stem cell proliferation both in vitro and in vivo, making it useful for research on neurological disorders. Ar-turmerone induces apoptosis in U937 cells.

Orcinol glucoside (Sakakin) (OG), an active constituent isolated from the rhizomes of Curculigo orchioides Gaertn, shows potent antioxidative and anxiolytic activities without sedative effects.

Protogracillin, a steroidal saponin isolated from Dioscorea zingiberensis Wright (DZW), may inhibit platelet aggregation (PAG) and thrombosis, potentially reducing the risk of cardiovascular diseases through its anti-thrombotic action.

Cycloposine, a steroidal alkaloid present in the roots and rhizomes of Veratrum californicum, is known to possess teratogenic properties.

Parishin (Parishin A) A is isolated from the rhizomes of Gastrodia elata. It has good neuroprotective effects against brain disorders.

Rehmannioside B, a desacyl derivative of Picrorhizaoside B, can be isolated from the methanol extract of Picrorhiza kurroa Royle ex Benth. rhizomes (Plantaginaceae) [1].

Progenin III palmitate, a steroid glycoside ester, is isolated from the rhizomes of Dioscorea cayenensis [1].

Picropodophyllin-4-O-β-D-glucopyranosyl-(1→6)-β-D-glucopyranoside (compound 17), a lignan, has been isolated from the roots and rhizomes of Podophyllum sinensis [1].

Donasine is a natural indole alkaloid that can be isolated from the rhizomes of Phragmites australis.

Acacetin 7-O-β-sophoroside, a flavonoid glycoside, has been isolated from the rhizomes and roots of valerian (Valeriana officinalis) [1].

1,3,6-Trihydroxy-2-methyl-9,10-anthraquinone-3-O-(6'-O-acetyl)-beta-D-xylopyranosyl-(1->2)-beta-D-glucopyranoside (Compound 20), a quinone derivative, is isolated from the roots and rhizomes of Madder [1].

(+)-5,7,4'-Trimethoxyafzelechin, a derivative of (+)-Afzelechin, functions as an α-glucosidase activity inhibitor and is isolated from the rhizomes of Bergenia ligulata [1].

(-)-Afzelechin, an antioxidant compound extracted from the rhizomes of Astilbe rivularis, demonstrates potent activity [1].

Norbergenin is a chemical compound. It is the O-demethylated derivative of bergenin. It can be isolated from rhizomes of Bergenia stracheyi.

7-O-Methylmangiferin (Standard) is a reference standard for research and analysis in studies involving 7-O-Methylmangiferin. 7-O-MethylMangiferin is an xanthone isolated from the rhizomes of Iris nigricans.

Parishin (Standard) is a reference standard for research and analysis in studies involving Parishin. Parishin (Parishin A) A is isolated from the rhizomes of Gastrodia elata. It has good neuroprotective effects against brain disorders.

Ethyl Cinnamate (Standard) is the certified analytical standard of Ethyl cinnamate intended for research and analytical applications, and Ethyl cinnamate is an orally active constituent of Kaempferia galanga rhizomes that exhibits anticancer, nematocidal, sedative, vasorelaxant, fragrance, and tissue-clearing properties, suppresses colorectal tumor growth via VEGFR2 pathway–mediated anti-angiogenesis, and inhibits high potassium- and phenylephrine-induced tonic contractions in rat aorta with IC50 values of 0.30 mM and 0.38 mM, respectively.