ref 1

REF1 peptide is a plant-inducing peptide that acts as a local wound signal to enhance plant regeneration. It is perceived by the receptor PORK1, and the REF1-PORK1-mediated signaling facilitates regeneration by activating the key transcription factor WIND1. This peptide is valuable for studies on the regeneration and transformation of recalcitrant crops.

E3330 is a potent and selective APE1(Ref-1) inhibitor, which suppressed NF-kappa B DNA-binding activity.

S-Adenosyl-L-methionine disulfate tosylate is a methyl donor with oral activity. S-Adenosyl-L-methionine disulfate tosylate is a dietary supplement with effective antidepressant and pain-relieving effects. S-Adenosyl-L-methionine disulfate tosylate also has anti-proliferative, pro-apoptotic and anti-metastatic effects in cancer. S-Adenosyl-L-methionine can be used in the research of liver diseases and osteoarthritis.

(Z)-Viaminate, a derivative of Retinoic acid, exhibits significant biological activity and is frequently used in pharmaceutical and dermatological applications [Ref. 1].

APX2014 is a novel potent and specific Ref-1 inhibitor, blocking in vitro cell proliferation and activating apoptosis via PARP cleavage.

APX2009 is a second-generation APE1/Ref-1 redox-specific inhibitor. APX2009 significantly reduces NFkB transcriptional activity, survivin mRNA, and survivin protein levels. APX2009 decreases prostate cancer cell proliferation and induces cell cycle arrest.