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(2)
By Target- Phosphatase
- Tie-2(2)
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Results for "
razuprotafib
" in TargetMol Product Catalog.- Inhibitors & Agonists2
Razuprotafib
AKB-9778
T167241008510-37-9
Razuprotafib (AKB-9778) is a protein tyrosine phosphatase ß (HPTPß) inhibitor with an IC50 of 50 nM. It effectively activates Tie-2 and provides protection against acute kidney injury.
- $253
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Razuprotafib sodium
AKB-9778 sodium
T2147211809275-69-1
Razuprotafib (AKB-9778) sodium is a potent and selective inhibitor of VE-PTP (HPTPη) catalytic activity, with an IC50 of 17 pM. It promotes TIE2 activation, enhances ANG1-induced TIE2 activation, and stimulates phosphorylation of signaling molecules in the TIE2 pathway, including AKT, eNOS, and ERK. Razuprotafib sodium also inhibits the structurally related phosphatase PTP1B with an IC50 of 780 nM. Additionally, apart from HPTPη (IC50 of 36 pM) and HPTPγ (100 pM), it has good selectivity for VE-PTP.
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