rRNA

2'-OMe-Guanosine is a modified nucleoside produced by the action of tRNA guanosine-2'-o-methyltransferase. 2'-OMe-Guanosine has a certain pro-apoptotic effect.

5S rRNA modificator (FAI), used in 5S rRNA RNA modification, is a suitable electrophile for 2'-hydroxyl acylation on structured RNA molecules.

Erythromycin (E-Mycin) is a Macrolide and Macrolide Antimicrobial. The physiologic effect of erythromycin is by means of Decreased Sebaceous Gland Activity.

Apramycin sulfate (Nebramycin II) is an aminoglycoside antibiotic.

Paromomycin binds specifically to the RNA oligonucleotide at the A site of bacterial 30S ribosomes, thereby causing misreading and premature termination of translation of mRNA and inhibition of protein synthesis followed by cell death. Paromomycin Sulfate (Aminosidine sulfate) is the sulfate salt form of paromomycin, a structural derivative of neomycin, an aminoglycoside antibiotic with amebicidal and bactericidal effects against predominantly aerobic gram-negative bacteria.

Clindamycin Phosphate is the phosphate salt form of clindamycin, a semi-synthetic, chlorinated broad-spectrum antibiotic produced by chemical modification of lincomycin. Clindamycin phosphate (Clindamycin 2-dihydrogen phosphate) is used in topical preparations.

5-fluorouridine is also known as FUrd, 5-Fluorouracil 1-beta-D-ribofuranoside, 5-Fur, or 5-Fluoro-uridine. 5-fluorouridine is a solid. This compound belongs to the pyrimidine nucleosides and analogues. These are compounds comprising a pyrimidine base attached to a sugar. 5-fluorouridine is known to target uridine phosphorylase. FUrd is often used in chemical and biochemical comparison studies with fluorouracil and thymine analogs.

Azithromycin hydrate (CP-62993 dihydrate) is a semi-synthetic macrolide antibiotic structurally related to ERYTHROMYCIN. It has been used in the treatment of Mycobacterium avium intracellulare infections, toxoplasmosis, and cryptosporidiosis.

Clindamycin hydrochloride monohydrate (Clindamycin alcoholate) is a protein synthesis inhibitor used orally, capable of diminishing virulence factor expression in Staphylococcus aureus at sub-minimum inhibitory concentrations (sub-MICs). It acts by suppressing Panton-Valentine leucocidin (PVL), toxic-shock-staphylococcal toxin (TSST-1), and alpha-haemolysin (Hla) production. Resistance to this compound emerges through enzymatic methylation at the antibiotic's 50S ribosomal subunit binding site (23S rRNA).

Amikacin disulfate (BAY-416651 sulfate) is a semi-synthetic aminoglycoside antibiotic derived from kanamycin A.

2',5-Difluoro-2'-deoxycytidine has potent anti-HCV activity and toxicity to rRNA.

3-Methyluridine is a modified nucleoside of cellular RNA.

EA25 has been identified in the clone library of the bacterial 16S rRNA gene sequence.

Paromamine is an antibiotic that targets and identifies ribosomal RNA (rRNA) components.

CX5461 is an rRNA synthesis inhibitor with oral activity that inhibits Pol I-driven rRNA transcription. CX5461 activates the DNA damage response and has antitumor activity in tumors such as ovarian cancer.

N4-Acetylcytidine-13C5 is a 13C-labeled version of N4-acetylcytidine (N4A), an endogenous nucleoside metabolite produced from tRNA degradation. It is synthesized by enzymes such as N-acetyltransferase 10. N4-acetylcytidine may play a role in maintaining the activation of the NLRP3 inflammasome by inducing the expression and release of HMGB1. Additionally, it influences the stability and translation efficiency of mRNA, tRNA, and rRNA (e.g., enterovirus71RNA) through modification. This compound is utilized in studies related to cancer, neuroinflammatory diseases, viral infections, and obesity.

Negamycin (hydrochloride) is a dipeptide antibiotic that can restore dystrophin expression in skeletal and cardiac muscles in the mdx mouse model of Duchenne muscular dystrophy (DMD). It binds to a segment of eukaryotic rRNA decoding site A. Negamycin (hydrochloride) is applicable in DMD research.

RNA MTase-IN-1 (Compound 47) is an inhibitor of RNA methyltransferase (RNA MTase), exhibiting an IC50 of 68 μM against 16S rRNA (m1A1408) methyltransferase (NpmA). It demonstrates significant inhibitory activity against aminoglycoside resistance linked to pathogens and is applicable in research on antibiotic-resistant bacterial infections.

Diazaborine inhibits maturation of rRNAs for the large ribosomal subunit. Diazaborine blocks ribosome biogenesis by inhibiting the AAA-ATPase Drg1. Diazaborine treatment causes, within minutes, a rapid redistribution of the protein from the nucleolus to t

4-Thiouridine (4-SU) is a photoactivatable ribonucleoside analog that is widely used for RNA analysis, including short-range RNA-RNA crosslinking and nascent RNA labeling. The crosslinking thio moiety is attached directly to the nucleotide base, thus 4-SU

7-Methylguanosine 5'-diphosphate (7-Methyl-GDP) sodium, a cap analog, is utilized in the synthesis of mRNA cap analogues[1].

Theaflavin digallate and lactic acid together could reduce herpes simplex virus transmission.

NusB-IN-1 (Compound 22r) is a highly effective, orally administered bacterial rRNA synthesis inhibitor with potent antimicrobial activity against MRSA and VRSA [1].

CX-5461 dihydrochloride is a potent, orally active inhibitor of Pol I-mediated rRNA synthesis that acts on HCT-116 cells (IC50: 142 nM), A375 cells (IC50: 113 nM) and MIA PaCa-2 cells (IC50: 54 nM), and to a lesser extent on Pol II (IC50 ≥ 25 μM).