quinacrine

Quinacrine methanesulfonate is a bioactive chemical.

Quinacrine dihydrochloride (Mepacrine dihydrochloride) is the dihydrochloride salt of the 9-aminoacridine derivative quinacrine with potential antineoplastic and antiparasitic activities.

Quinacrine dihydrochloride hydrate possesses antiprotozoal and anti-infective properties and exhibits multi-target biological activity; it inhibits voltage-gated sodium channels (which are involved in the generation and conduction of action potentials) and aldehyde oxidase activity, and acts as a riboflavin antagonist to interfere with riboflavin-related protein interactions; Furthermore, quinacrine has been used in in vitro models to study the regulation of prion misfolding processes.

Quinacrine Dihydrochloride Dihydrate is an orally available antimalarial agent capable of crossing the blood-brain barrier. It exhibits anticancer activity by inhibiting WNT/TCF and topoisomerase, inducing autophagy and apoptosis, and activating p53. Quinacrine is an acridine dye derivative used for DNA and RNA staining in fixed cells (Ex/Em=436/525 nm).

Quinacrine analog 34 is a potent autophagy inhibitor (EC₅₀ = 0.5 μM, LD₅₀ = 27 μM) that upregulates the protein levels of the autophagy marker LC3-II and induces lysosomal deacidification.

Quinacrine acetate is a histamine N-methyltransferase inhibitor.

Mepacrine (Erion) is an acridine derivative formerly widely used as an antimalarial. It is used in cell biological experiments as an inhibitor of phospholipase A2.

d-Atabrine hydrochloride is the active enantiomer of quinacrine and has anti-pr virus activity.

l-Atabrine dihydrochloride displays antiprion activity. l-Atabrine dihydrochloride is a less active enantiomer of quinacrine.

DQ661 is a potent inhibitor of PPT1 and a dimeric quinacrine autophagy (autophagy) inhibitor. It effectively suppresses the activity of mTORC1 and reduces protein expression levels of pS6K T389 and pS6 S240-244. Additionally, DQ661 exhibits anticancer properties.