pyrrolizidine

Usaramine (Mucronatine) demonstrates phytotoxicity against Lactuca sativa var. Carrascoy (lettuce) assessed as inhibition of seed germination at 50 ug/cm2 after 24 hr.

Seneciphylline, one of the hepatotoxic pyrolizidine alkaloids, has mutagenic activity in Drosophila and their transfer into rat milk.Seneciphylline can significantly increased the activities of epoxide hydrase and glutathione-S-transferase but cause reduc

Retrorsine selectively inhibits hepatocyte proliferation and following liver injury evokes small hepatocyte-like progenitor cells. Retrorsine can be used for the research of hepatocellular injury.

1,2-Epoxy-1-hydroxymethylpyrrolizidine is a useful organic compound for research related to life sciences and the catalog number is T125765.

Monocrotaline is an 11-membered macrocyclic pyrrolizidine alkaloid extracted from the seeds of Crotalaria plants. It inhibits organic cation transporters OCT-1 and OCT-2, with IC50 values of 36.8 µM and 1.8 mM, respectively. Monocrotaline exhibits antitumor activity and shows certain cytotoxicity against liver cancer cells such as HepG2. It is also commonly used to induce pulmonary arterial hypertension models in rodents.

Lamellarin D (Lamellarine D), a hexacyclic pyrrolizidine alkaloid isolated from marine invertebrates, is a mitochondria-targeted topoisomerase I inhibitor and a pro-apoptotic agent.

Lasiocarpine is a pyrrolizidine alkaloid, it has acute cytotoxicity in human and hepatic cell lines.

Senkirkin is a pyrrolizidine alkaloid with hepatotoxicity.

Ligularine is a hepatotoxic otonecine-type pyrrolizidine alkaloid isolated from Ligularia hodgsonii, a Chinese traditional antitussive medicine.

Clivorine is an otonecine pyrrolizidine alkaloid from the genus Ligularia.

Dehydrolasiocarpine is a pyrrolizidine alkaloid.

Dehydroretrorsine is a pyrrolizidine alkaloid metabolite.

Isatidine is a pyrrolizidine alkaoid.

Isoline is a pyrrolizidine alkaloid isolated from the traditional Chinese medicine Ligularia duciformis.

Jaconine hydrochloride is a Pyrrolizidine alkaloid.

Ligularidine is a pyrrolizidine alkaloid.

Lindelofine is a pyrrolizidine alkaloid.

Retusamine is a pyrrolizidine alkaloid.

Rosmarinine is a non-toxic pyrrolizidine alkaloid.

Supinine is a pyrrolizidine alkaloid.

Australine is a pyrrolizidine alkaloid originally isolated fromC. australethat has enzyme inhibitory activities.1,2,3It is an inhibitor of glucoamylase (IC50= 5.8 μM) that also inhibits glucosidase I, sucrase, maltase, andA. nigerα-glucosidase (IC50s = 20, 28, 35, and 28 μM, respectively).2,3Australine is selective for these enzymes over glucosidase II, α- and β-mannosidase, and α- and β-galactosidase up to 500 μM, β-glucosidase, with only 5% inhibition at 66 μM, as well as isomaltase and trehalase (IC50= 97 and 160 μM, respectively). Australine (500 μg/ml) inhibits glycoprotein processing of viral glycoproteins in influenza virus-infected MDCK cells and induces the accumulation of glycoproteins.2 1.Molyneux, R.J., Benson, M., Wong, R.Y., et al.Australine, a novel pyrrolizidine alkaloid glucosidase inhibitor from Castanospermum australJ. Nat. Prod.51(6)1198-1206(1988) 2.Tropea, J.E., Molyneux, R.J., Kaushal, G.P., et al.Australine, a pyrrolizidine alkaloid that inhibits amyloglucosidase and glycoprotein processingBiochemistry28(5)2027-2034(1989) 3.Kato, A., Kano, E., Adachi, I., et al.Australine and related alkaloids: easy structural confirmation by 13C NMR spectral data and biological activitiesTetrahedron Asymmetry14(3)325-331(2003)

(+)-Intermedine, a pyrrolizidine alkaloid (PA), exhibits significant cytotoxic activity against neural progenitor cells (NPCs).

Jacobine N-oxide is a pyrrolizidine alkaloid compound found in thrips-resistant Senecio hybrids.

Erucifoline, a pyrrolizidine alkaloid, is present in the aerial components of Senecio aquaticus.