pyrrolizidine

Retrorsine selectively inhibits hepatocyte proliferation and following liver injury evokes small hepatocyte-like progenitor cells. Retrorsine can be used for the research of hepatocellular injury.

1,2-Epoxy-1-hydroxymethylpyrrolizidine is a useful organic compound for research related to life sciences and the catalog number is T125765.

Lamellarin D (Lamellarine D), a hexacyclic pyrrolizidine alkaloid isolated from marine invertebrates, is a mitochondria-targeted topoisomerase I inhibitor and a pro-apoptotic agent.

Monocrotaline is an 11-membered macrocyclic pyrrolizidine alkaloid extracted from the seeds of Crotalaria plants. It inhibits organic cation transporters OCT-1 and OCT-2, with IC50 values of 36.8 µM and 1.8 mM, respectively. Monocrotaline exhibits antitumor activity and shows certain cytotoxicity against liver cancer cells such as HepG2. It is also commonly used to induce pulmonary arterial hypertension models in rodents.

Lasiocarpine is a pyrrolizidine alkaloid, it has acute cytotoxicity in human and hepatic cell lines.

Senkirkin is a pyrrolizidine alkaloid with hepatotoxicity.

Ligularine is a hepatotoxic otonecine-type pyrrolizidine alkaloid isolated from Ligularia hodgsonii, a Chinese traditional antitussive medicine.

Isatidine is a pyrrolizidine alkaoid.

Supinine is a pyrrolizidine alkaloid.

(+)-Intermedine, a pyrrolizidine alkaloid (PA), exhibits significant cytotoxic activity against neural progenitor cells (NPCs).

Usaramine (Mucronatine) demonstrates phytotoxicity against Lactuca sativa var. Carrascoy (lettuce) assessed as inhibition of seed germination at 50 ug cm2 after 24 hr.

Jacobine N-oxide is a pyrrolizidine alkaloid compound found in thrips-resistant Senecio hybrids.

Erucifoline, a pyrrolizidine alkaloid, is present in the aerial components of Senecio aquaticus.

Echimidine N-oxide, a pyrrolizidine alkaloid, exhibits significant inhibitory activity against acetylcholinesterase (AChE) with an IC50 value of 0.347 mM.

Indicine N-oxide (NSC 132319), a pyrrolizidine alkaloid, serves as an antitumor agent in pediatric cancer and solid tumors research.

7-Acetylintermedine is a hepatotoxic botanical pyrrolizidine alkaloid.

Senecionine acetate (O-Acetylsenecionine), a pyrrolizidine alkaloid, inhibits the sequestration of Ca2+ in both extramitochondrial and mitochondrial compartments, likely through the inactivation of free sulfhydryl groups [1].

Rinderine N-oxide, a pyrrolizidine alkaloid, is present in R. graeca [1].

Adonifoline is a hepatotoxic pyrrolizidine alkaloid.

Seneciphylline, one of the hepatotoxic pyrolizidine alkaloids, has mutagenic activity in Drosophila and their transfer into rat milk.Seneciphylline can significantly increased the activities of epoxide hydrase and glutathione-S-transferase but cause reduc

Senecionine n-oxide is a major product of pyrrolizidine nucleic alkaloid biosynthesis in unusual root cultures of Trichoderma lucidum.Senecionine N-oxide (Senecionine oxide) has antitumor activity but induces hepatic sinusoidal obstruction syndrome.Senecionine n-oxide acts as a chelating tracer for N-oxide.

Seneciphylline N-oxide is a pyrrolizidine alkaloid obtained from Emilia sonchifolia and is the dehydrogenation product of Senecionine N-oxide.

Desacetyldoronine is a hepatotoxic pyrrolizidine alkaloid.

Echimidine ((+)-Echimidine) is a natural pyrrolizidine alkaloid and direct AChE inhibitor that also has binding activity to muscarinic receptors and 5-HT2, and can be used to study Alzheimer's disease.