psi 7409

PSI-7409 is the active 5'-triphosphate metabolite of Sofosbuvir (PSI-7977).

PSI-7409 tetrasodium is the pharmacologically active 5′-triphosphate metabolite of sofosbuvir (PSI-7977) that directly inhibits hepatitis C virus NS5B RNA-dependent RNA polymerase, with IC50 values of 1.6, 2.8, 0.7, and 2.6 μM against GT 1b_Con1, GT 2a_JFH1, GT 3a, and GT 4a NS5B polymerases, respectively, PSI-7409 tetrasodium is widely used to study antiviral mechanisms and genotype-specific polymerase inhibition.

Pan-RAS-IN-2 (compound 6A) is an orally active molecular glue that targets RAS by inducing ternary complex formation with cyclophilin A (CYPA) and RAS in the ON state, leading to potent inhibition of downstream RAF binding and pERK signaling with an IC50 of 0.3 nM in AsPC-1 cells, Pan-RAS-IN-2 demonstrates strong antiproliferative effects in RAS-mutant cancer cell lines, supporting research into targeted therapies for colorectal and pancreatic cancers.