pro-fluorescent

NBD-F (4-Fluoro-7-nitrobenzofurazan) is a fluorescent derivatization agent used for amino acid analysis.

Acriflavine (Acriflavinium chloride 3,6-Acridinediamine mix) is a papain-like protease (PL(pro)) inhibitor, a fluorescent dye for labeling high molecular weight RNAs, has antimicrobial and anticancer activity, inhibits SARS-CoV-2 and other β-coronaviruses, and can be used for research on leukemia. be used to study leukemia.

MeO-Succ-Arg-Pro-Tyr-AMC is an analog of 7-amido-4-methylcoumarin and serves as a sensitive fluorescent substrate for chymotrypsin-like proteases, with excitation at 341 nm and emission at 441 nm.

MeOSuc-AAPV-AMC (MeOSuc-Ala-Ala-Pro-Val-AMC) is a tetrapeptide that is a fluorescent substrate for human leukocyte and porcine pancreatic elastase.

DABCYL-Glu-Arg-Nle-Phe-Leu-Ser-Phe-Pro-EDANS is a fluorescent dye used as a fluorogenic substrate for aspartyl proteinase from the human malaria parasite [1]. It should be stored protected from light.

Boc-Val-Pro-Arg-MCA hydrochloride (Boc-Val-Pro-Arg-MCA HCl) is a sensitive fluorescent substrate for the determination of trypsin-like serine proteases activity.

Boc-Val-Pro-Arg-MCA TFA is a sensitive fluorescent substrate that is a thrombin substrate for the determination of trypsin-like serine protease activity.

Gly-Pro-AMC hydrobromide (Gly-Pro-AMC HCl) is a specific fluorescent dye used in cytofluorescence assays to detect Dipeptidyl peptidase IV (DPP-IV) activity.

Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 (FS-6) is a quenched, fluorescent MMP peptide substrate designed for real-time quantification of MMP enzymatic activity. As an extended variant of the MMP substrate (FS-1), it demonstrates increased specificity against collagenases (MMP-1, MMP-8, MMP-13) and MT1-MMP, with higher specificity constants (Ex/Em=325 nm/400 nm). [1]

Z-Gly-Pro-Arg-AMC hydrochloride is a synthetic peptide that is often used as a trypsin and histone K fluorescent substrate to measure enzyme activity, which fluoresces when the enzyme is cleaved from the peptide.

Z-Gly-Pro-Arg-4MβNA is a thrombin substrate that, when cleaved by thrombin, releases 4-methoxy-2-naphthylamine (4MβNA). The liberated 4MβNA reacts with 5-nitrosalicylaldehyde, forming an insoluble yellow fluorescent product, which indicates the site of thrombin activity [1].

PRO-F, a photoactivable hydrogen sulfide (H2S) donor, possesses reactive oxygen species (ROS) scavenging properties and emits a fluorescent signal upon light activation, enabling real-time tracking of H2S release. Its activation is independent of endogenous substance consumption and facilitates intracellular H2S delivery, safeguarding cells from excessive ROS-induced damage. Notably, PRO-F has demonstrated efficacy in promoting chronic wound healing in diabetic models [1].

Z-Gly-Pro-AMC serves as a fluorogenic substrate that, when hydrolyzed by prolyl endopeptidase, produces the highly fluorescent compound, 7-amido-4-methylcoumarin (λ ex =380 nm, λ em =465 nm) [1].