phosphoglucose

6-Phosphogluconic acid is a potent and competitive inhibitor of phosphoglucose isomerase (PGI), with an apparent Ki of 0.048 mM for glucose 6-phosphate and 0.042 mM for fructose 6-phosphate as the substrate.

Phosphoglucose isomerase, E.coli (EC 5.3.1.9), is a crucial enzyme in the interconversion of D-glucose-6-phosphate and D-fructose-6-phosphate. It catalyzes the second step of glycolysis and plays a role in glycogen synthesis. This enzyme is highly conserved in both bacteria and eukaryotes.

Phosphoglucose isomerase, Bacillus subtilis (EC 5.3.1.9), is an essential enzyme involved in the interconversion between D-glucose-6-phosphate and D-fructose-6-phosphate. It catalyzes the second step of glycolysis and participates in glycogen synthesis. This enzyme is highly conserved across both bacteria and eukaryotes.

Phosphoglucose isomerase, Saccharomyces cerevisiae (EC 5.3.1.9), is a vital enzyme for the interconversion of D-glucose-6-phosphate and D-fructose-6-phosphate. It facilitates the second step of glycolysis and is involved in glycogen synthesis, being highly conserved in both bacteria and eukaryotes.

Phosphoglucose isomerase, bacillus stearothermophilus, is a highly conserved glycolytic enzyme and dimerase. It catalyzes the isomerization of glucose-6-phosphate into fructose-6-phosphate.

Phosphoglucose isomerase, bacillus stearothermophilus, is a highly conserved glycolytic enzyme and dimerase. It catalyzes the isomerization of glucose-6-phosphate into fructose-6-phosphate.

Uridine 5′-diphosphoglucose disodium salt (UDP-glucose) is a natural product and a P2Y14 receptor agonist (EC50 = 0.35 μM) with endogenous activity and selectivity. It is used for studying mechanisms related to cardiac inflammation following myocardial infarction/reperfusion injury.

Uridine 5′-diphosphoglucose-13C6 disodium isodium) is the 13C-labeled analog of uridine 5′-diphosphoglucose disodium salt. Uridine 5′-diphosphoglucose disodium salt (UDP-D-Glucose disodium salt) serves as a precursor for glucose-containing oligosaccharides, polysaccharides, glycoproteins, and glycolipids within animal tissues and certain microorganisms. Additionally, uridine 5′-diphosphoglucose disodium salt (UDP-D-Glucose disodium salt) functions as an agonist for the P2Y14 receptor, a GPCR in the neuroimmune system.

Uridine-5'-diphosphoglucose pyrophosphorylase is a biochemical reagent that serves as a biological material or organic compound, used in life sciences research.

Uridine diphosphate glucose (UDP-glucose) is a pyrimidine nucleotide sugar, serving as a precursor for oligosaccharides, polysaccharides, glycoproteins, and glycolipids containing glucose. It is a key intermediate in carbohydrate metabolism and participates in numerous enzymatic reactions, acting as a P2Y14 agonist.

ADP-Glucose (ADPG) is an immediate precursor used in the biosynthesis, by glucose addition, of storage polysaccharides in plants, green algae, and cyanobacteria, as well as structural polysaccharides in certain bacteria.[1],[2] It is used by amylose synthases or starch synthases in plastids in the production of amylose, amylopectins, starch, and other polysaccharides. ADPG is normally generated within plastids, although it can be biosynthesized in the cytoplasm of certain grasses and imported into plastids by a membrane-bound transporter.[3]

2-deoxy-D-Glucose-13C is intended for use as an internal standard for the quantification of 2-deoxy-D-glucose by GC- or LC-MS. 2-deoxy-D-Glucose (T6742) is a glucose antimetabolite and an inhibitor of glycolysis. It inhibits hexokinase, the enzyme that converts glucose to glucose-6-phosphate, as well as phosphoglucose isomerase, the enzyme that converts glucose-6-phosphate to fructose-6-phosphate.

RmlA-IN-2 is a potent inhibitor of 1-phosphoglucose thymidyltransferase (RmlA) (IC50: 0.303 μM).RmlA-IN-2 affects the monosaccharide l-rhamnose biosynthetic pathway and affects bacterial cell wall permeability.

Paromomycin (Sulfate Salt) is an aminoglycoside that is active against Gram-negative and many Gram-positive bacteria as well as some protozoa and cestodes. Paromomycin in combination with sodium stibogluconate has proven to be effective in African and Indian VL (visceral leishmaniasis) and improves survival in African VL[3]. PS (Paromomycin Sulfate) is effective for elimination of B. coli without hematological side effects[4]. The activity of phosphoglucose isomerase was slightly inhibited by 10(-3) M paromomycin sulfate while those of hexokinase, phosphofructokinase and glucose-6-phosphate dehydrogenase were not inhibited[5]. In addition, with regard to correlation of endotoxemia with renal impairment, endogenous creatinine clearance and p-aminohippurate clearance were significantly improved (P less than 0.02) in those patients whose endotoxemia disappeared on paromomycin sulfate administration. Paromomycin sulfate seems to be effective in the prevention of endotoxemia and the associated renal impairment in cirrhosis in man[6]. Significantly higher frequencies of resistance to paromomycin, kanamycin, neomycin and tobramycin were observed in S. aureus isolates from PS (paromomycin supplemented) birds. Paromomycin supplementation resulted in resistance to aminoglycosides in bacteria of PS turkeys. Co-selection for resistance to other antimicrobial agents was observed in E. coli isolates[7].

Glucose 6-phosphate isomerase (GPI), also known as phosphoglucose isomerase/phosphoglucoisomerase (PGI) or phosphohexose isomerase (PHI), is a highly conserved glycolytic and dimeric enzyme often used in biochemical studies that catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate [1].

6-Phosphogluconic acid trisodium is a highly potent competitive phosphoglucose isomerase (PGI) inhibitor and an endogenous metabolite in the body. Its inhibition constants Ki for 6‑phosphoglucose and 6‑phosphofructose are 48 μM and 42 μM, respectively.

D-Fructose 6-phosphate dipotassium is an endogenous metabolite found in saliva that influences cell growth and autophagy. It is produced by the hydrolysis of Fructose-1,6-bisphosphatase (FBPase). Under the action of phosphoglucose isomerase, D-Fructose 6-phosphate dipotassium can be converted into D-glucose 6-phosphate . This compound acts as a sugar intermediate in both the glycolysis and pentose phosphate pathways. D-Fructose 6-phosphate dipotassium is used in research related to Lewy body dementia.