pep 1

Pep-1 (uncapped), which has 21 amino acid residues, is a known carrier peptide that delivers full-length native proteins in vitro and in vivo.

PEP1 is a biologically active peptide that interacts with POPC supported lipid bilayers (SLBs), binding at low concentrations, while higher concentrations induce POPC SLB lysis.

Analog of Pep1-TGL

Peptide containing the 'TGL' motif that corresponds to the C-terminus of GluR1 subunit

PEP1 acetate is a p21-mimetic peptide that serves as a specific proliferating cell nuclear antigen (PCNA) binding inhibitor. It arrests the cell cycle in the S phase by competitively blocking the interaction between PCNA and DNA polymerase delta, thereby interfering with DNA replication.

Pep1-DNP conjugate 9 is a functionalized peptide composed of a DNP-hapten and an FGFR1-binding peptide. It exhibits good affinity for FGFR1, with a dissociation constant (KD) of 5.01 μM. This compound effectively recruits anti-DNP antibodies to the surface of FGFR1-positive cells, inhibits FGF2-induced proliferation of rat skeletal myoblasts, and induces apoptosis. In mouse models, Pep1-DNP conjugate 9 demonstrates antitumor activity.

Pep-1-Cysteamine, a chimeric cell-penetrating peptide (CPP), exhibits primary amphipathicity and facilitates the translocation of active proteins across biological membranes into cells [1].

Pep-1-Cysteamine TFA is a chimeric cell-penetrating peptide (CPP) with primary amphipathic properties. It possesses the capability to traverse biological membranes and facilitate the intracellular delivery of active proteins.

NOTA-Pep-1L specifically targets the IL13RA2 receptor and is utilized for tumor imaging. Additionally, it is employed in the synthesis and research of radiolabeled conjugates (RDC).

DOTA-Pep-1L TFA is a peptide resulting from the conjugation of DOTA with Pep-1L, where Pep-1L specifically targets the IL13RA2 receptor. DOTA-Pep-1L TFA is utilized in PET imaging and research on tumor-targeted therapies.

DOTA-Pep-1L is a peptide formed by the conjugation of DOTA with Pep-1L, where Pep-1L is a peptide specifically targeting the IL13RA2 receptor. DOTA-Pep-1L is applicable in PET imaging and research focused on tumor-targeted therapy.

pep-10L peptide is an antagonist of glycoprotein VI (GPVI) with Ki values of 180 μM for CPR, 225 μM for GPO-1, and 179 μM for Type 1 collagen. It exhibits antithrombotic properties.

Pep19-2.5, a synthetic antitoxin peptide, inhibits the intracellular signaling cascade triggered by endotoxins by blocking the activity of lipopeptides (LP) and lipopolysaccharides (LPS) mediated through both transmembrane and cytosolic pattern recognition receptors (PRRs). This action disrupts the signaling pathways that normally result in inflammation and cell pyroptosis [1].

AtPep1 is an inducible peptide found in plants. It can activate the transcription of the defense gene defensin (PDF1.2) and stimulate the production of H2O2, both of which are components of the innate immune response against pathogens. AtPep1 can be isolated from Arabidopsis leaf extracts.

CyPep-1 is a novel cationic lytic peptide with antitumor activity. It exerts potent cytotoxicity by interacting with the negatively charged membranes of cancer cells. CyPep-1 demonstrates strong cell lytic activity against cancer cells both in vitro and in vivo, making it useful for researching solid tumors.

PDpep1.3 is a peptide inhibitor targeting α-synuclein, which disrupts the direct interaction between α-synuclein and CHarged Multivesicular body Protein 2B (CHMP2B). This disruption enables PDpep1.3 to restore the degradative functions of endosomes and lysosomes, reducing the levels and aggregation of α-synuclein, and safeguarding dopaminergic neurons from α-synuclein-induced degeneration. PDpep1.3 is useful for research on neurodegenerative diseases and protein-protein interactions.

Potassium 1-carboxyvinyl hydrogenphosphate (PEP-K) is involved in glycolysis and gluconeogeneis. In glycolysis, PEP is metabolized by Pyruvate Kinase to yield pyruvate. In plants, PEP is involved in the formation of aromatic amino acids as well as in the carbon fixation pathway.

Prolyl Endopeptidase Inhibitor 1 is a potent inhibitor of prolyl endopeptidase (PEP; PE)(Ki : 15 nM) , has anti-amnesic effect.

EHMT2-IN-1 is a potent EHMT inhibitor used in blood disorder and cancer research, with IC50 values all below 100 nM for EHMT1 peptide, EHMT2 peptide, and cellular EHMT2.

AG1433 is a tyrosine kinases inhibitor that acts as a direct and selective inhibitor of photosynthetic PEP carboxylase and an inhibitor of PDGFR-β, Flk-1, and angiogenesis.

S 17092 (S 17092-1) is a potent inhibitor of cerebral prolyl-endopeptidase (PEP) with an IC50 value of 1.2 nM, used in research on memory impairment and cognitive disorders related to cerebral aging [1].

Peplomycin (Bleomycin PEP; Pepleomycin), an analogue of Bleomycin, exhibits significant antitumor activity with reduced pulmonary toxicity. It induces apoptosis in the oral squamous carcinoma cell line SSCKN and causes pulmonary fibrosis in rats [1] [2] [3] [4].

Z-Thioprolyl-Thioproline is a prolyl endopeptidase inhibitor derived from bovine brain, exhibiting inhibition constants of IC50 = 16 µM and Ki = 37 µM. This compound is utilized in the investigation of neurological disorders, including memory and cognitive disorders [1].

Camstatin TFA, a 25-residue fragment derived from the IQ motif of PEP-19, effectively binds to calmodulin and inhibits neuronal nitric oxide (NO) synthase, demonstrating its functional activity [1].