penetratin

Penetratin, a peptide derived from the amphiphilic Drosophila Antennapedia homeodomain.

Penetratin-Arg is an antimicrobial agent used as a drug delivery vehicle [1].

PNC-28 acetate, a peptide derived from the mdm-2-binding domain (residues 17–26) of the p53 protein featuring a penetratin sequence for membrane crossing, is utilized in pancreatic cancer research [1] [2].

PNC-28, a peptide derived from the mdm-2-binding domain of p53 protein (residues 17–26), incorporates a membrane-crossing penetratin sequence. This compound is utilized in pancreatic cancer research [1] [2].

EB1 peptide (Penetrating analog), an amphipathic cell-penetrating peptide (CPP) derivative of Penetratin, holds promise for intracellular drug delivery research [1].

Shepherdin is a synthetic peptide mirroring amino acids 79-87 of human survivin, acting as an inhibitor of the survivin-heat shock protein 90 (Hsp90) interaction. It specifically targets the N-terminal domain of Hsp90, blocking the survivin-Hsp90 interaction in human reticulocyte extracts at a 150 µM concentration. Conjugates of Shepherdin with cell-permeable peptides, such as penetratin or the HIV Tat sequence, exhibit anticancer properties both in vitro and in vivo.