p38a inhibitor 2

P38α Inhibitor 2, a potent and selective inhibitor of p38α MAPK, exhibits a pIC50 value of 9.6. It also demonstrates inhibition of the hERG ion channel (IC50=27 μM) and maintains promising selectivity, with <30% inhibition across a panel of 51 protein kinases at a 10 μM concentration and a broad specificity against 141 other biological targets[1].

CK1-IN-2 (compound Nr.4) is a potent CK1 inhibitor with IC50 values of 123, 19.8, 26.8, and 74.3 nM for CK1a, CK1d, CK1e, and p38a, respectively, and is used in DUX4 overexpression-associated diseases, such as muscular dystrophy.

CK1-IN-2 (compound Nr.4) hydrochloride is an effective inhibitor of CK1, exhibiting inhibitory IC50 values of 123 nM, 19.8 nM, 26.8 nM, and 74.3 nM against CK1a, CK1d, CK1e, and p38a respectively.