p 32.5

Tofimilast (CP-325366), a PDE4 inhibitor, is used potentially for the treatment of asthma and chronic obstructive pulmonary disease.

NP3-253 is an orally active NLRP3 inhibitor that can cross the blood-brain barrier. It serves as a tool for further exploring the biological properties of NLRP3 in models of peripheral and neuroinflammation.

Naboctate is a synthetic cannabinoid receptor agonist. It has antiemetic, sedative, anxiolytic and anti-glaucoma properties.

Naboctate hydrochloride is the hydrochloride form of naboctate, a synthetic cannabinoid receptor agonist. It has antiemetic, sedative, anxiolytic and anti-glaucoma properties.

Ac-DEVD-CHO (TFA) is a peptide inhibitor of caspase-3 (Ki=230 pM) and caspase-7. It reduces caspase-3 activity and apoptosis (apoptosis) induced by Prostaglandin E2 in rat cortical neurons. Ac-DEVD-CHO (TFA) shows potential for research in neurodegenerative diseases and cancer.

PIC1 PATFA is the trifluoroacetate form of PIC1 PA. PIC1 PA TFA is a peptide composed of 15 amino acids and serves as an effective PIC1 analog capable of inhibiting complement activation mediated by the classical pathway.

Colulintide is an analog of amylin, utilized in obesity research.

MACTIDE-V is an orally active and selective peptide-drug conjugate targeting CD206. This compound delivers Verteporfin to CD206+ tumor-associated macrophages (TAM), thereby inhibiting the YAP/TAZ signaling pathway. It facilitates YAP exclusion from the nucleus, induces TAM polarization toward an anti-tumor phenotype, enhances phagocytosis and antigen presentation, and promotes T cell infiltration and NK cell activity. MACTIDE-V suppresses primary tumor growth and lung metastasis in triple-negative breast cancer (TNBC) mouse models.

Biotinyl-α-CGRP (human) TFA is a peptide identified through peptide screening, which serves as a research tool primarily utilizing immunoassays to gather active peptides. This method is applicable in studying protein interactions, conducting functional analyses, and screening antigen epitopes, particularly useful in the research and development of active molecules.

MP196 is a cationic hexapeptide antibiotic (antibiotic) that targets bacterial cytoplasmic membranes. It exhibits rapid bactericidal action by disrupting membrane integrity, inhibiting cellular respiration, and blocking cell wall synthesis. MP196 holds promise for research on infections caused by drug-resistant bacteria.

CGN peptide is a polypeptide composed of 13 D-amino acids, abbreviated as CGN peptide. It is the retro-inverso isomer of the L-peptide TGN (TGNYKALHPHNG), capable of targeting siRNA delivery to the blood-brain barrier (BBB). d(CGNHPHLAKYNGT) can be utilized in Alzheimer's disease (AD) research.

Riztunitide exhibits anti-inflammatory activity.

EEKAR-AMC serves as a substrate for PsCaspase. When the EEKAR-AMC peptide is incubated with metabolites from infected cells expressing PsTIR, it undergoes cleavage by PsCaspase.

Lysylcysteine (L-Lysyl-L-cysteine)TFA is a dipeptide composed of lysine and cysteine.