ossification

SR11237 is a Pan retinoid X receptor (RXR) agonist. SR11237 causes RXR/RXR homodimers to form and transactivate a reporter gene containing a RXR-response element.

Secalciferol is a Vitamin D metabolite,Secalciferol is a possibly anti-inflammatory steroid which is involved in bone ossification.

LDN-212854 (BMP Inhibitor III), a novel BMP inhibitor, exhibits greater selectivity for BMP versus the TGF-β type I receptors; possesses differences towards ALK2(IC50=1.3 nM) versus ALK1/3 compared to other inhibitors.

The compound AVSEHQLLHDKGKSIQDLRRRFFLHHLI-{Aib}-EIHTAYRFGG facilitates bone ossification and has potential applications in the study of conditions associated with osteogenic insufficiency or diminished bone mineral density (BMD), including osteoporosis [1].

Zilurgisertib fumarate (INB-000928 fumarate, NBU-928 fumarate), a selective ALK-2 inhibitor, is in development for the treatment of ectopic ossification and progressive fibrodysplasia ossificans.

2,3-Dimercaptopropanesulfonate (DMPS) acts as a mercury chelator. It lowers renal mercury concentrations while elevating urinary mercury levels in both uninephrectomized and normal rats treated with mercuric chloride. In a mouse model of developmental toxicity induced by heavy metals, DMPS (administered at 180 or 360 mg/kg per day for four days) mitigates methylmercury chloride-induced increases in embryotoxicity and fetal and maternal mortality, while also preventing the reduction in fetal bone ossification when given to pregnant mice.