orai1

RO2959 Hydrochloride (RO2959 HCl) is a potent and selective inhibitor of CRAC channel(IC50: 402 nM). It is also a potent inhibitor of human IL-2.

Anti-Orai1 Antibody is a humanized monoclonal antibody targeting Calcium Release-Activated Calcium Modulator 1 (Orai1/CRACM1). Orai1 forms the pore subunit of the Calcium Release-Activated Calcium (CRAC) channel on the plasma membrane, mediating Store-Operated Calcium Entry (SOCE). In T lymphocytes, antigen receptor stimulation depletes endoplasmic reticulum calcium stores, triggering STIM1 to activate Orai1 and induce sustained calcium influx, a critical step for NFAT activation and cytokine (e.g., IL-2) production. This antibody specifically binds to the extracellular loops of Orai1, blocking the channel pore or disrupting STIM1-Orai1 coupling, thereby inhibiting SOCE and downstream immune responses. It is widely used in research on autoimmune diseases, inflammation, and calcium signaling-dependent tumors.

Jamaicin (AnCoA4) is a natural product, a STIM1-Orai1 channel inhibitor that blocks calcium influx and suppresses T cell activation. This compound possesses cellular permeability and is used for research related to immunomodulation, demonstrating potential anti-inflammatory activity.

Zegocractin (CM-4620) is an inhibitor of calcium-release activated calcium (CRAC) channels.

IA65 is a selective small molecule agonist that enhances Orai1 channel-mediated calcium influx and activates calcium-dependent inactivation mechanisms. IA65 serves as an ideal tool for studying intracellular calcium homeostasis and is also used to investigate the migratory behavior of vascular smooth muscle cells, skeletal muscle function, and immune system.

MRS1845 is an ORAI1 inhibitor and calcium entry (SOCE) blocker that blocks VP-induced SOCE, OS, and Ca(2+) deposition.

Pyr10 is a pyrazole derivative and a selective TRP cation 3 inhibitor that distinguishes between receptor-operated TRPC3 and native stromal interaction molecule 1 (STIM1)/Orai1 channels. Pyr10 inhibits Ca2+ influx in carbachol-stimulated TRPC3-transfected HEK293 cells (IC50: 0.72 μM) and has an IC50 of 13.08 μM for store-operated Ca2+ entry in BRL-2H3 cells.