ophiopogonin-d

Ophiopogonin D is a natural product,and is a CYP2J3 inducer that significantly inhibits Ang II induced NF-κB nuclear translocation. Ophiopogonin D(OPD) significantly inhibited the in vitro and in vivo growth of prostate cells via RIPK1, OPD may be developed as a potential anti-prostate cancer agent.

Ophiopogonin D' can activate SIRT1 in a dose-dependent manner. Ophiopogonin D' also noncompetitively inhibits UGT1A6 and UGT1A10.

25(S)-Ophiopogonin D, a steroidal glycoside, abrogates STAT3 signaling cascade and exhibits anti-cancer activity by causing GSH/GSSG imbalance in lung carcinoma. 25(S)-Ophiopogonin D is therefore used in cancer signaling research systems to investigate STAT3 pathway regulation, redox imbalance mechanisms, and glutathione homeostasis disruption in lung carcinoma cellular models.