o-11

O-11 is an analog of the fully saturated, 14-carbon fatty acid myristic acid, in which the methylene group at position 11 is replaced with oxygen. It is highly effective and selective at killingTrypanosoma brucei, the protozoan parasite responsible for African sleeping sickness, exhibiting an LD50of less than 1 μM in a cell culture assay.1,2The toxic effects of O-11 appear to be caused by its ability to inhibit the incorporation of a single myristate into the GPI anchor of the variant surface glycoprotein (VSG), a protein critical for evading the host immune response.1O-11 exhibits essentially no anti-fungal activity when assayed usingC. neoformans, but does have a minor inhibitory effect on HIV-1 replication in T-lymphocytes.3 1.Doering, T.L., Raper, J., Buxbaum, L.U., et al.An analog of myristic acid with selective toxicity for African trypanosomesScience2521851-1854(1991) 2.Doering, T.L., Lu, T., Werbovetz, K.A., et al.Toxicity of myristic acid analogs toward African trypanosomesProceedings of the National Academy of Sciences of the United States of America919735-9739(1994) 3.Langner, C.A., Lodge, J.K., Travis, S.J., et al.4-Oxatetradecanoic acid is fungicidal for Cryptococcus neoformans and inhibits replication of human immunodeficiency virus IThe Journal of Biological Chemisty267(24)17159-17169(1992)

BIO-11006 acetate salt (901117-03-1 free base) is a polyglycosylated alanine rich C kinase substrate (MARCKS) inhibitor similar to MANS peptides.

Tenacigenin B, a component of the plant Poria cocos, is identified as 3-O-β-Allopyranosyl-(1→4).

11-O-Galloylbergenin is isolated from of Mallotus philippinensis with antioxidant and antiplasmodial activities.

11-O-β-D-glucopyranosyl thamnosmonin is a coumarin glucoside extractable from the roots of Angelica apaensis that exhibits weak inhibitory effects on rabbit platelet aggregation induced by PAF, AA, and ADP [1].

11-O-Syringylbergenin, a bergenin derivative, has been isolated from the entire plant of Corylopsis willmottiae Rehd. et Wils [1].

3-O-Acetyl-11-hydroxy-beta-boswellic acid, the precursor of 3-O-acetyl-9,11-dehydro-beta-boswellic acid (a 5-lipoxygenase inhibitor),

(1R,6R,9R)-6,9,11-Trihydroxy-4,7-megastigmadien-3-one 11-O-glucoside is a natural product for research related to life sciences. The catalog number is TN6201 and the CAS number is 289914-68-7.

11-O-Siamenoside I is a natural product that can be used in related research in the field of life sciences. Its product number is TN8605.

11-O-Mogroside IIIA1 is a natural product that can be used in related research in the field of life sciences. Its product number is TN8824.

4,5-Dioxo-4,5-seco-11(13)-cadinen-12-oic acid is a useful organic compound for research related to life sciences and the catalog number is T125973.

BO-1158 is an antibacteria agent.

RO-11-7330 is a bioactive chemical.

Tetrahydro-11-deoxy cortisol (THS) is the primary urinary metabolite of 11-deoxycortisol. Urinary excretion of THS is elevated in patients with 11β-hydroxylase deficiency, a condition resulting from mutations in the cytochrome P450 (CYP) isoform CYP11B1. Urinary levels of THS are also elevated in patients with adrenocortical carcinoma (ACC) and adrenocortical adenoma (ACA) but are higher in patients with ACC compared to ACA.

10,11-Dihydro-11-oxodibenzo[b,f][1,4]thiazepine is a useful organic compound for research related to life sciences. The catalog number is T65432 and the CAS number is 3159-07-7.

8-Chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-one is a useful organic compound for research related to life sciences. The catalog number is T65438 and the CAS number is 31251-41-9.

Tetrahydro-11-dehydrocorticosterone is an inhibitor of 11β-hydroxysteroid dehydrogenase [1].

LASSBio-1135 is an orally effective antagonist of TRPV1 and inhibitor of TNF-α production.

Fos-Choline-ISO-11 is a useful organic compound for research related to life sciences. The catalog number is TF0024 and the CAS number is 869647-65-4.

1,11b-Dihydro-11b-hydroxymaackiain is a natural product from Derris robusta.

1,11b-Dihydro-11b-hydroxymedicarpin is a natural product from Derris robusta.

BIO-11006 Inhibitor is a nebulized 10-amino acid peptide compound that inhibits the protein kinase C substrate known as myristoylated alanine-rich C-kinase substrate (MARCKS) protein, offering potential immunoregulatory and antitumor activities.

AKBA (3-O-Acetyl-11-keto-beta-boswellic acid), a natural component from frankincense, is a novel activator of Nrf2.

Thalidomide-O-amido-C6-NH2 TFA (Cereblon Ligand-Linker Conjugates 11 TFA) is a synthesized E3 ligase ligand-linker conjugate comprising a Thalidomide-based cereblon ligand and a linker.