nojirimycin

Nojirimycin is the parent compound of a class of antibiotics and glycosidase inhibitors obtained from a class of Streptomyces species.

Nojirimycin 1-sulfonic acid is a reagent used in biochemical reactions.

1-Deoxynojirimycin (Moranoline) is a potent α-glucosidase inhibitor, suppressing postprandial blood glucose, thereby possibly preventing diabetes mellitus.

AMP-Deoxynojirimycin (AMP-DNM) is a potent inhibitor of ceramide glucosyltransferase and GCase 2, as well as GlcCer biosynthesis, and is utilized in the study of Parkinson's disease and diabetes.

Homonojirimycin is an alpha-glucosidase inhibitor.

1-Deoxynojirimycin hydrochloride (Moranoline) is a potent and selective inhibitor of alpha-glucosidase, most commonly found in mulberry leaves. Duvoglustat is used to suppress the elevation of postprandial hyperglycemia.

1-Deoxymannojirimycin hydrochloride, a selective α1,2-mannosidase inhibitor (IC50: 20 μM), also inhibits HIV-1 strains but exhibits poor antiviral activity.

Deoxynojirimycin (dNM) tetrabenzyl ether is an intermediate for the synthesis of glucosylceramide synthase inhibitors such as 1-dNM, a glucose analog that potently inhibits α-glucosidase I and II.

The effect of N-(3-phenyl-2-propenyl)-1-deoxynojirimycin (ppDNM) on the lectin binding to HIV-1 glycoprotein was analyzed by using biotinylated lectins of various sugar specificities as probes. ppDNM potentially inhibited HIV-1-induced syncytium formation and viral infectivity of HIV-1 without cytotoxicity. The lectin binding assay showed that ppDNM treatment reduced Con A binding to gp120 of HIV-1.

Deoxyfuconojirimycin hydrochloride acts as a specific competitive inhibitor targeting human liver α-L-fucosidase.

1-Deoxynojirimycin, a potent glucose analog, inhibits α-glucosidase I and II effectively. Its derivative, N-5-Carboxypentyl-1-deoxynojirimycin, serves as a ligand for glucosidase I and II purification, utilizing carboxypentyl groups for affinity chromatography resin linkage. Furthermore, N-5-Carboxypentyl-1-deoxynojirimycin demonstrates comparable or superior inhibition of glucosidase compared to 1-deoxynojirimycin, with inhibition constants (Ki) of 0.45 µM and 2.1 µM, respectively, for pig liver glucosidase I.

N-Nonyldeoxynojirimycin (NN-DNJ) is an inhibitor of acid α-glucosidase and α-1,6-glucosidase with IC50 values of 0.42 μM and 8.4 μM, respectively.

Deoxymannojirimycin hydrochloride is a reagent used in biochemical reactions.

N-5-Carboxypentyl-deoxymannojirimycin is a biochemical reagent used in glycoscience research. Glycoscience examines the structure, synthesis, biology, and evolution of sugars. This field covers carbohydrate chemistry, glycan formation and degradation enzymology, protein-glycan interactions, and the role of glycans in biological systems, and it is closely linked to fundamental research, biomedicine, and biotechnology.

N-Ethyldeoxynojirimycin hydrochloride is a reagent used in biochemical reactions.

Miglustat (NB-DNJ) is an alkylated product of imino sugar deoxynojirimycin.It is an inhibitor of glucosylceramide synthase, primarily to treat Type I Gaucher disease (GD1).

N-Methylmoranoline is an inhibitor of α-glucosidase.

Lucerastat（NBDGJ） is an orally available inhibitor of Glucosylceramide Synthase (GCS) with therapeutic potential for Fabry disease. GCS is a key enzyme in sphingolipid synthesis and inhibition of its activity reduces the accumulation of harmful substrates.

UR-MK299 is a NPY Y1 receptor antagonist.

Kahweol oleate is emi-syntetic derivative of kahweol, a natural product found in coffee beans. It exhibits a wide variety of biological activities, including inhibiting RANKL-induced osteoclast generation, inducing cell cycle arrest and apoptosis in oral squamous cell carcinoma cells, preventing aflatoxin B1 induced DNA adduct formation, and suppressing H2O2-induced DNA damage and oxidative stress.

Famiraprinium is a competitive antagonist at the GABA receptor site.

Miglustat hydrochloride (N-Butyldeoxynojirimycin hydrochloride) is an inhibitor of glucosylceramide synthase and can be used for studies about Type I Gaucher disease.