nojirimycin

Nojirimycin is the parent compound of a class of antibiotics and glycosidase inhibitors obtained from a class of Streptomyces species.

Nojirimycin 1-sulfonic acid is a reagent used in biochemical reactions.

1-Deoxynojirimycin (Moranoline) is a potent α-glucosidase inhibitor, suppressing postprandial blood glucose, thereby possibly preventing diabetes mellitus.

Homonojirimycin is an alpha-glucosidase inhibitor.

1-Deoxynojirimycin hydrochloride (Moranoline) is a potent and selective inhibitor of alpha-glucosidase, most commonly found in mulberry leaves. Duvoglustat is used to suppress the elevation of postprandial hyperglycemia.

1-Deoxymannojirimycin hydrochloride, a selective α1,2-mannosidase inhibitor (IC50: 20 μM), also inhibits HIV-1 strains but exhibits poor antiviral activity.

AMP-Deoxynojirimycin (AMP-DNM) is a potent inhibitor of ceramide glucosyltransferase and GCase 2, as well as GlcCer biosynthesis, and is utilized in the study of Parkinson's disease and diabetes.

Deoxynojirimycin (dNM) tetrabenzyl ether is an intermediate for the synthesis of glucosylceramide synthase inhibitors such as 1-dNM, a glucose analog that potently inhibits α-glucosidase I and II.

The effect of N-(3-phenyl-2-propenyl)-1-deoxynojirimycin (ppDNM) on the lectin binding to HIV-1 glycoprotein was analyzed by using biotinylated lectins of various sugar specificities as probes. ppDNM potentially inhibited HIV-1-induced syncytium formation and viral infectivity of HIV-1 without cytotoxicity. The lectin binding assay showed that ppDNM treatment reduced Con A binding to gp120 of HIV-1.

Deoxyfuconojirimycin hydrochloride acts as a specific competitive inhibitor targeting human liver α-L-fucosidase.

1-Deoxynojirimycin, a potent glucose analog, inhibits α-glucosidase I and II effectively. Its derivative, N-5-Carboxypentyl-1-deoxynojirimycin, serves as a ligand for glucosidase I and II purification, utilizing carboxypentyl groups for affinity chromatography resin linkage. Furthermore, N-5-Carboxypentyl-1-deoxynojirimycin demonstrates comparable or superior inhibition of glucosidase compared to 1-deoxynojirimycin, with inhibition constants (Ki) of 0.45 µM and 2.1 µM, respectively, for pig liver glucosidase I.

N-Nonyldeoxynojirimycin (NN-DNJ) is an inhibitor of acid α-glucosidase and α-1,6-glucosidase with IC50 values of 0.42 μM and 8.4 μM, respectively.

Deoxymannojirimycin hydrochloride is a reagent used in biochemical reactions.

N-5-Carboxypentyl-deoxymannojirimycin is a biochemical reagent used in glycoscience research. Glycoscience examines the structure, synthesis, biology, and evolution of sugars. This field covers carbohydrate chemistry, glycan formation and degradation enzymology, protein-glycan interactions, and the role of glycans in biological systems, and it is closely linked to fundamental research, biomedicine, and biotechnology.

N-Ethyldeoxynojirimycin hydrochloride is a reagent used in biochemical reactions.