nnk

NNK is a nitrosated derivative of nicotine that activates the ERK1/2 and PKCα signaling pathways, induces Bcl2 phosphorylation at Ser70, and activates c-Myc at Thr58 and Ser62, thereby promoting the proliferation and survival of human lung cancer cells, and is commonly used to establish lung cancer mouse models.

NNK-D4 is the deuterated form of NNK (T20533).

NNK-13C6 is the compound NNK labeled with carbon-13 (\(^13C\)).

Vofopitant (GR 205171) is a potent NK1 receptor antagonist with anxiolytic and antiemetic activity for the study of post-traumatic stress disorder (PTSD).

Ibodutant is an effective and selective tachykinin NK2 receptor antagonist (pKi: 10.1).

MEN 10207 is an antagonist of tachykinin.

BI-1347 is a potent, selective inhibitor of CDK8/cyclinC (IC50: 1 nM). It shows tumor growth inhibition in an in vivo xenograft model.

LMN-NKA acetate is a modified Neurokinin A (4-10) and selective NK2R (Neurokinin 2 receptor) agonist that induces bladder contraction and urination/defecation in rats, and can be used for studying smooth muscle contraction.

S27 protein acetate is a polypeptide encoded by the MRPS27 gene.

(R,S)-N-Nitrosoanabasine (NAB) is a tobacco-specific N-nitrosamine (TSNA) identified in tobacco products and electronic cigarettes. It inhibits the cytochrome P450 (CYP) isoform CYP2A13 metabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) into 4-oxo-4-(3-pyridyl) butanal (OPB), 4-hydroxy-1-(3-pyridyl)-1-butanone (HPB), and 4-oxo-4-(3-pyridyl) butanoic acid (OPBA), with respective Ki values of 0.23, 0.87, and 0.5 µM. While NAB is not carcinogenic in hamsters, it is carcinogenic in mice.

Garlic oil can inhibit lung tumors caused by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) by inducing second-phase drug metabolizing enzymes.

PBITC (4-Phenylbutyl isothiocyanate) is an orally active antitumor compound that inhibits NNK-induced lung cancer in mice. This compound is a sulfur analog of ISC-4.