mouse pnp

Forodesine hydrochloride (BCX-1777 hydrochloride), a potent inhibitor of human lymphocyte proliferation, effectively induces apoptosis in leukemic cells by elevating dGTP levels. This compound is an orally active, highly potent purine nucleoside phosphorylase (PNP) inhibitor, demonstrating IC50 values between 0.48 to 1.57 nM across human, mouse, rat, monkey, and dog PNP.

Forodesine (BCX-1777) is an orally active and potent purine nucleoside phosphorylase (PNP) inhibitor, a new purine nucleoside analog, inhibitor of human lymphocyte proliferation, induces apoptosis in leukemic cells by increasing dGTP levels, and may be useful in the study of cutaneous T-cell lymphomas.

Peldesine (BCX 34) is an effective, competitive, reversible, and orally active inhibitor of purine nucleoside phosphorylase. Peldesine inhibits T-cell proliferation with an IC50 of 800 nM. Peldesine can be used in research on cutaneous T-cell lymphoma, psoriasis and HIV infection.

AMP-PNP tetralithium（Adenylyl-imidodiphosphate tetralithium） is a non-hydrolyzable ATP analog that fully occupies ATP-binding sites without undergoing enzymatic hydrolysis, thereby providing stable and controlled experimental conditions for dissecting ATP-dependent biological processes. AMP-PNP is widely used to investigate enzyme activity, kinase regulation, DNA and RNA metabolism, ion channel function, and protein complex assembly in biochemical and structural biology studies.

Peldesine (BCX 34) dihydrochloride is a potent, competitive, reversible, and orally active inhibitor of purine nucleoside phosphorylase (PNP), with IC50 values of 36 nM, 5 nM, and 32 nM against human, rat, and mouse red blood cell (RBC) PNP, respectively. Additionally, it inhibits T-cell proliferation with an IC50 of 800 nM, showing promise for research into cutaneous T-cell lymphoma, psoriasis, and HIV infection [1] [2] [3] [4].

(R)-C12-200, an ionizable cationic lipid (pKa = 7.25) and isomer of C12-200, is utilized in forming lipid nanoparticles (LNPs) for delivering mRNA in vivo. When administered intravenously, LNPs containing (R)-C12-200 with mRNA encoding Cre recombinase result in a smaller increase in the percentage of tdTomato+ hepatocytes, endothelial cells, and Kupffer cells in the liver of Ai14 mice compared to LNPs with (S)-C12-200. Additionally, LNPs with (R)-C12-200 carrying mRNA for purine nucleoside phosphorylase (PNP), an E. coli enzyme that transforms fludarabine phosphate into the cytotoxic agent 2-fluoroadenine, prompt intratumoral PNP expression and diminish tumor volume in a FaDu head and neck squamous cell carcinoma (HNSCC) mouse xenograft model when fludarabine phosphate is co-administered.