mitosis — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T40247	Ethofumesate		Others
	Ethofumesate is a chiral herbicide. Ethofumesate acts by inhibiting mitosis and reducing photosynthesis and plant respiration.		Others
T8561	Apcin		APC
	Apcin is a potent and competitive inhibitor of anaphase-promoting complex/cyclosome (APC/C(Cdc20)) E3 ligase activity. Apcin competitively inhibits APC/C-dependent ubiquitylation by binding to Cdc20 and preventing substr...		APC
T7200	TAK-960		PLK
	TAK-960 is an orally bioavailable, selective inhibitor of Plks with IC50 values of 0.8, 16.9, and 50.2 nM for Plk1, Plk2, and Plk3, respectively.		PLK
TQ0317	R1530	R-1530,R 1530	VEGFR , FGFR , FLT , PDGFR
	R1530 is a multikinase inhibitor with antineoplastic and antiangiogenesis activities.		VEGFR , FGFR , FLT , PDGFR
T19664	ON1231320	GBO-006	Apoptosis , PLK
	ON1231320 (GBO-006) is a Polo-like kinase 2 (PLK2) inhibitor.		Apoptosis , PLK
T1992	Mertansine	DM1,Maytansinoid DM1	Microtubule Associated
	Mertansine (DM1) refers to the thiol-containing maytansinoid, DM1 (N2'-deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine) attached to a monoclonal antibody through reaction of the thiol group with the SPP (N-succinimidyl 4...		Microtubule Associated
T21654	1-Oleoyl lysophosphatidic acid sodium	1-Oleoyl lysophosphatidic acid sodium salt	LPA Receptor
	1-Oleoyl lysophosphatidic acid sodium (1-Oleoyl lysophosphatidic acid sodium salt) salt is an Endogenous agonist of LPA1 and LPA2		LPA Receptor
T3643	HMN-176		PLK
	HMN-176 is a stilbene derivative which inhibits mitosis, interfering with polo-like kinase-1 (plk1).		PLK
T22305	Dexrazoxane	ICRF-187	Others
	Dexrazoxane (ICRF-187) is an anticancer drug used to block mitosis and arrest dividing cells. It is an iron chelator and provides cardioprotection against anthracycline toxicity.		Others
T6213	Vinorelbine ditartrate	Vinorelbine Tartrate,Nor-5'-anhydrovinblastine ditartrate,KW-2307,Navelbine tartrate	Microtubule Associated , Autophagy
	Vinorelbine ditartrate (KW-2307), a semi-synthetic vinca alkaloid, interacts with tubulin resulting in mitosis inhibition.		Microtubule Associated , Autophagy
T9014	SKI-178		Apoptosis , S1P Receptor
	SKI-178 is a sphingosine kinase 1 (SphK1) inhibitor with IC50 of 0.1-1.8 μM. It induces prolonged mitosis followed by apoptotic cell death through the intrinsic apoptotic cascade. The sustained activation of CDK1 during ...		Apoptosis , S1P Receptor
T4057	Hoechst 33258 trihydrochloride	Hoechst 33258,Pibenzimol,Bisbenzimide,H 33258 trihydrochloride,bisBenzimide H 33258 trihydrochloride,HOE 33258	Parasite
	Hoechst 33258 trihydrochloride (Bisbenzimide) is a benzimidazole anti-filarial agent. it is fluorescent when it binds to certain nucleotides in DNA, thus providing a tool for the study of DNA replication. it also interfe...		Parasite
T3567	SU 4942		Others
	SU-4942 is a modulator of tyrosine kinase signaling. SU-4942 has inhibitory effects on endothelial cell mitosis induced by VEGF and endothelial cell growth factor (ECGF).		Others
T29059	UMK57	UMK 57,UMK-57	Kinesin
	UMK57 is a CENP-Ei and MCAK enhancer, selectively promoting k-MT attachment error correction to inhibit chromosome missegregation of small molecule compounds, and can improve chromosome separation conservation by disrupt...		Kinesin
T3352	XL413		cholecystokinin , Casein Kinase , Pim , CDK
	XL-413 is an orally bioavailable cell division cycle 7 homolog (CDC7) kinase inhibitor with potential antineoplastic activity. XL-413 binds to and inhibits the activity of CDC7, which may result in the inhibition of DNA ...		cholecystokinin , Casein Kinase , Pim , CDK
T24398	Lenaldekar	LDK	Akt , IGF-1R , S6 Kinase
	Lenaldekar (LDK) inhibits T-cell expansion and autoimmune encephalomyelitis. Lenaldekar causes dephosphorylation of members of the PI3 kinase/AKT/mTOR pathway and delays sensitive cells in late mitosis.		Akt , IGF-1R , S6 Kinase
T16987	TAO Kinase inhibitor 1		Others , MAPK
	TAO Kinase inhibitor 1 delays mitosis and induces mitotic cell death. TAO Kinase inhibitor 1 is a selective and ATP-competitive thousand-and-one amino acid kinases inhibitor (IC50s: 11 to 15 nM for TAOK1 and 2, respectiv...		Others , MAPK
T5699	SSE15206		Apoptosis , Microtubule Associated
	SSE15206 is a microtubule polymerization inhibitor that overcomes multidrug resistance. Causes aberrant mitosis resulting in G2/M arrest due to incomplete spindle formation in cancer cells.		Apoptosis , Microtubule Associated
T26585	AK301	AK-301,AK 301	Apoptosis , Microtubule Associated
	AK301 is a potent and selective inhibitor of tubulin polymerization and an effective sensitizer of cancer cells to apoptotic ligands (EC50 < 200 nM). Colon cancer cells arrested in mitosis with AK301 readily underwent a ...		Apoptosis , Microtubule Associated
T70407	Cemadotin free base	LU103793 free base	Microtubule Associated
	Cemadotin free base(LU103793 free base) is a novel anti-limiting peptide , an analog of Dolastatin 15, a naturally occurring cytotoxic peptide that blocks mitosis and inhibits microtubules (tubulin) with a Ki of 1 μM. Ce...		Microtubule Associated