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Cat No. | Product Name | Synonyms | Targets |
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T27719 | KD-026 | SLx 4090,SLx4090,KD026,SLx-4090 | CETP |
KD-026 (SLx 4090), a microsomal triglyceride transfer protein (MTP) inhibitor(IC50 = 8.0 nM), is used in type 2 diabetes studies. | |||
T20625 | Prochloraz | Sporgon,Prelude | Estrogen Receptor/ERR , AhR , Androgen Receptor , Antifungal |
Prochloraz (Prelude) is a broad-spectrum contact imidazole fungicide. Prochloraz inhibits human placental microsomal aromatase in vitro (IC50 = 40 nM). Prochloraz also acts as an estrogen receptor (IC50s = 25 μM) and and... | |||
T23861 | CAY10526 | CAY-10526,BTH,CAY 10526 | Prostaglandin Receptor |
CAY10526 (BTH) is a selective mPGES-1 inhibitor that acts as an inhibitor of the NF-κB signaling pathway. | |||
T12856 | SC-26196 | Others | |
SC-26196 is an orally active inhibitor of Delta6 desaturase (D6D) with IC50 of 0.2 µM in a rat liver microsomal assay, with antiinflammatory properties. | |||
T2545 | Lomitapide Mesylate | BMS-201038 mesylate,AEGR-733 mesylate | CETP |
Lomitapide Mesylate (BMS-201038 mesylate) is a methanesulfonic acid form of lomitapide, a small molecule inhibitor of microsomal triglyceride transfer protein. | |||
T16928 | SR144528 | Cannabinoid Receptor | |
SR144528 is an antagonist of the CB2 receptor (Ki = 0.6 nM) and inhibits microsomal ACAT activity (IC50 = 3.6 μM). | |||
T14523 | Beauvericin | Others , Acyltransferase | |
Beauvericin, a Fusarium mycotoxin, inhibits acyl-CoA:cholesterol acyltransferase (ACAT) in rat liver microsomal enzyme assays with an IC50 value of 3 μM. | |||
T28089 | MPGES-1 Inhibitor-1 | Prostaglandin Receptor | |
mPGES-1 Inhibitor-1 is a novel selective inhibitor of microsomal prostaglandin E synthase-1 (mPGES-1) with anti-inflammatory and analgesic activity for the study of acute liver injury. | |||
T27084 | Crisdesalazine | AAD2004,AAD 2004,AAD-2004 | Prostaglandin Receptor |
Crisdesalazine (AAD 2004) is an inhibitor of microsomal prostaglandin E2 synthase-1 (mPGES-1). Crisdesalazine reduces autophagosome formation, axonopathy, and motor neuron degeneration, improving motor function and incre... | |||
T30506 | BMS-212122 | UNII-0Z473OO6GB,BMS212122,BMS 212122 | CETP |
BMS-212122 (UNII-0Z473OO6GB) is a potent inhibitor of microsomal triglyceride transfer protein (MTP) and has shown hypolipidemic effects in animal studies.BMS-212122 significantly reduced lipid content and monocyte-deriv... | |||
T16865 | SCH28080 | ATPase , Proton pump | |
SCH28080 is a reversible and K+-competitive inhibitor of gastric H+/K+-ATPase with an IC50 value of 20 nM (rabbit microsomal membrane).SCH28080 is a potent inhibitor of acid secretion in vivo with anti-ulcer activity, an... | |||
T15006 | Dirlotapide | CP742033,Slentrol | Others , CETP |
Dirlotapide (CP742033) is an intestinal selective microsomal triglyceride transfer protein (MTP) inhibitor. It reduces body weight in diabetic dogs.Dirlotapide reduces food intake in a dose-dependent manner, possibly by ... | |||
T31992 | Granotapide | CETP | |
Granotapide is a microsomal triglyceride transfer protein (MTP) inhibitor that treats and rather prevents atherosclerosis, coronary artery disease, metabolic syndrome, obesity, diabetes mellitus, prediabetes mellitus, an... | |||
T21738 | PF-9184 | Prostaglandin Receptor | |
PF-9184 is a potent and selective inhibitor of human microsomal prostaglandin E synthase-1 (mPGES-1), IC50 =16.5 nM. PF-9184 inhibits IL-1β-induced PGE2 synthesis in vitro. | |||
T6267 | Lomitapide | AEGR-733,BMS-201038 | CETP |
Lomitapide (AEGR-733) is a small molecule inhibitor of microsomal triglyceride transfer protein (MTP), an enzyme located in the lumen of the endoplasmic reticulum responsible for absorbing dietary lipids and transferring... | |||
T37825 | CAY10434 | P450 | |
CAY10434 is an active inhibitor of CYP4A hydroxylase with an IC50 value of 8.8 nM in human kidney microsomal test. The maximum contractile value (Emax) of CAY 10434 was 6764 mg in improving the contractile process of ang... | |||
T1055 | Ifosfamide | NSC109724,Isophosphamide | DNA Alkylator/Crosslinker , DNA/RNA Synthesis |
Ifosfamide (NSC-109724) alkylates and forms DNA crosslinks, thereby preventing DNA strand separation and DNA replication. Ifosfamide is a synthetic analog of the nitrogen mustard cyclophosphamide with antineoplastic acti... | |||
T9394 | CHIKV-IN-2 | Dehydrogenase | |
CHIKV-IN-2, a chemical compound, exhibits potent inhibitory activity against the enzyme Dihydroorotate Dehydrogenase (DHODH), crucial for pyrimidine synthesis affecting various viruses' replication. It serves as an effec... | |||
T72470 | Estrone O-sulfamate | Estrone 3-O-sulfamate | Others |
Estrone O-sulfamate (Estrone 3-O-sulfamate) is a potent inhibitor of steroid sulfatase (STS). Estrone O-sulfamate is a placental microsomal inhibitor (P.M.) with IC50 values of 18 nM. Estrone O-sulfamate showed inhibitor... | |||
T35610 | 2,5-dimethyl Celecoxib | Apoptosis , Wnt/beta-catenin , Prostaglandin Receptor | |
2,5-dimethyl Celecoxib is a derivative of celecoxib that does not inhibit COX-2 (IC50 = >100 μM).1 It does inhibit microsomal prostaglandin E synthase-1 (mPGES-1) in HeLa cells (IC50 = 15.6 μM) and reduces prostaglandin ... | |||
T36696 | DMBA | ||
7,12-Dimethylbenz[a]anthracene (DMBA) is a polycyclic aromatic hydrocarbon (PAH) that has been found in tobacco smoke and diesel exhaust and has carcinogenic activity.1,2It undergoes metabolic activation by numerous enzy... | |||
T6412 | CVT-12012 | Stearoyl-CoA Desaturase (SCD) | |
CVT-12012 is an orally bioavailable inhibitor of stearoyl-CoA desaturase (SCD; IC50 = 6.1 nM in HepG2 cells). | |||
T12765 | RPR107393 free base | Others | |
RPR107393 free base is a selective inhibitor of squalene synthase(rat liver microsomal squalene synthase, with an IC50 of 0.8 nM). | |||
T33110 | M 79193 | M79193,M-79193 | |
M 79193 induces total hepatic microsomal cytochrome P-450. | |||
T13418 | CP-319340(free base) | Others | |
CP-319340 free base is a inhibitor of microsomal triglyceride transfer protein (MTP) . | |||
T24223 | JTT 130 | JTT-130,JTT130 | |
JTT 130 is an agent of hypolipidemic. It inhibits microsomal triglyceride transfer protein. | |||
T15570 | Implitapide | AEGR 427 | CETP |
Implitapide is an inhibitor of microsomal triglyceride transfer protein (MTP). | |||
T25440 | FR20 | FR-20,FR 20 | |
FR20 is a human microsomal prostaglandin synthase 1 (mPGES 1) inhibitor. | |||
T16158 | PF-02575799 | Adenosine Receptor | |
PF-02575799 is an inhibitor of microsomal triglyceride transfer protein (MTP) (IC50: 0.77±0.29 nM). | |||
T10504 | Implitapide Racemate | Others | |
Implitapide Racemate is the racemate of Implitapide. Implitapide is an inhibitor of microsomal triglyceride transfer protein (MTP). | |||
T12100 | MPGES1-IN-3 | Prostaglandin Receptor | |
mPGES1-IN-3 is a potent and selective inhibitor of microsomal prostaglandin E2 synthase-1 (mPGES-1) . | |||
T35005 | Usistapide | R-256918,JNJ-16269110,JNJ16269110,R256918,JNJ 16269110,R 256918 | |
UsISpide(JNJ-16269110 R256918) is an inhibitor of microsomal triglyceride transfer protein (MTTP) under development for the treatment of obesity and type 2 diabetes. | |||
T23596 | A-933548 | A933548,A 933548 | |
A-933548 is a potent Calpain inhibitor. A-933548 features enhanced selectivity versus related cysteine protease cathepsins, favorable microsomal stability, and efficacy in cellular assays. | |||
T16504 | PF-4693627 | Prostaglandin Receptor | |
PF-4693627 is an effective and selective microsomal prostaglandin E synthase-1 inhibitor (IC50=3 nM). It is used for the treatment of inflammation caused by osteoarthritis (OA) and rheumatoid arthritis (RA). | |||
T23598 | A-953227 | A 953227,A953227 | |
A-953227 is a highly effective and selective inhibitor of calpain. A-953227 features enhanced selectivity versus related cysteine protease cathepsins, favorable microsomal stability, and efficacy in cellular assays. | |||
T14564 | BI-4924 | Others | |
BI-4924 is an inhibitor of phosphoglycerate dehydrogenase (PHGDH) (IC50=3 nM). It has excellent Microsomal and hepatocytic stability. Intracellular trapping of BI-4924 disrupts serine biosynthesis at 72 h ( IC50: 2200 nM... | |||
T68375 | KD026-metabolite | ||
KD026-metabolite, is a metabolite of KD-026. KD026, also known as SLx-4090, is a microsomal triglyceride transfer protein (MTTP) inhibitor potentially for the treatment of type 2 diabetes. | |||
T38666 | CP-346086 dihydrate | ||
CP-346086 dihydrate is a potent and orally active inhibitor of microsomal triglyceride transfer protein (MTP), exhibiting an IC50 value of 2.0 nM for both human and rodent MTP. This compound effectively lowers plasma cho... | |||
T39000 | Zaloglanstat | GRC-27864,ISC-27864 | |
Zaloglanstat (ISC-27864) is a potent inhibitor of microsomal prostaglandin E synthase-1 (mPGES-1). It is utilized in the research of various conditions, including asthma, osteoarthritis, rheumatoid arthritis, acute or ch... | |||
T39303 | CP-346086 | ||
CP-346086 is a highly potent and orally bioavailable inhibitor of microsomal triglyceride transfer protein (MTP), exhibiting an IC50 value of 2.0 nM against both human and rodent MTP. This compound effectively reduces pl... | |||
T61504 | PKM2 activator 3 | ||
PKM2 activator 3 is a highly potent compound that activates PKM2, with an AC 50 value of 90 nM. It exhibits excellent Caco-2 permeability, a low efflux ratio, and remarkable microsomal stability. PKM2 activator 3 is part... | |||
T37840 | 20-hydroxy Prostaglandin F2α | 20-hydroxy Prostaglandin F2α | |
20-hydroxy Prostaglandin F2α (20-hydroxy PGF2α) is the ω-oxidation product of PGF2α. Cultured type II alveolar cells from pregnant rabbits metabolize exogenous PGF2α via microsomal cytochrome P450 ω-oxidation, producing ... | |||
T38143 | Elaidamide | ||
Elaidamide is a fatty acid amide that has been found in the cerebrospinal fluid of sleep-deprived cats.1 It inhibits rat microsomal epoxide hydrolase (mEH; Ki = 70 nM).2 Elaidamide also inhibits porcine pancreatic and hu... | |||
T62850 | IRAK4-IN-13 | ||
IRAK4-IN-13 (compound 21) is a selective and potent IRAK4 inhibitor (IC50: 0.6 nM). iRAK4-IN-13 has a high metabolic clearance, with an intrinsic human liver microsomal (HLM) clearance of 96 μL/min/mg. | |||
T74520 | TD-802 | ||
TD-802 (Compound 33c), an androgen receptor (AR) PROTAC degrader, exhibits strong microsomal stability and demonstrates potent antitumor efficacy in vivo, making it suitable for research on metastatic castration-resistan... | |||
T60346 | PDE4-IN-10 | ||
PDE4-IN-10 (compound 7a) is a potent inhibitor of PDE4, with an IC 50 of 7.01 μM for PDE4B. PDE4-IN-10 exhibits selectivity, microsomal stability, inhibition of TNF-α and no major toxicities in vitro [1]. | |||
T74781 | UT-11 | ||
UT-11 is a potent brain-permeable inhibitor of microsomal prostaglandin E synthase-1 (mPGES-1), exhibiting IC50 values of 0.10 μM and 2.00 μM for the inhibition of PGE2 production in human (SK-N-AS) and murine (BV2) cell... | |||
T83187 | AChE-IN-41 | ||
AChE-IN-41 (Compound 2), a Galantamine-Memantine hybrid, possesses cholinesterase inhibitory capabilities. This compound demonstrates enhanced plasma stability and similar microsomal stability in vitro but has a reduced ... | |||
T79272 | BDM91514 | ||
BDM91514 enhances antibiotic efficacy by inhibiting AcrB, effectively curbing the proliferation of E. coli BW25113 with an EC90 of 8 μM when coupled with 8 μg/mL Pyridomycin. Additionally, BDM91514 exhibits favorable pla... | |||
T79440 | DprE1-IN-5 | ||
DprE1-IN-5 (Compound 10), a potent DprE1 inhibitor, exhibits anti-TB activity with an MIC of 4 μM against the Mtb H37Rv strain and demonstrates antimycobacterial efficacy against drug-resistant strains. Additionally, it ... |
Cat No. | Product Name | Synonyms | Targets |
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T5261 | (E)-Oct-2-enoic acid | trans-2-Octenoic acid,2-Octenoate,2-Octenoic acid | Others , Endogenous Metabolite |
(E)-Oct-2-enoic acid (2-Octenoate) is a normal organic acid produced by hepatic microsomal oxidation of aliphatic aldehydes and is a metabolite naturally found in the urine and plasma. | |||
TN1818 | Kaempferol 3-O-β-D-glucuronide | Kaempferol-3-O-glucuronide,Kaempferol-3-beta-O-glucuronide,Kaempferol-3-glucuronide | IL Receptor |
Kaempferol 3-O-β-D-glucuronide (Kaempferol-3-beta-O-glucuronide)e has antioxidant activity. Flavonoid glucuronides can be deconjugated by microsomal α²-glucuronidase from various human cells. | |||
TN1674 | Garcinone D | Reactive Oxygen Species , Nrf2 , STAT | |
Garcinone D shows significant cytotoxicity against the CEM-SS cell line, with IC(50) value of 3.2 microg/ml; it exhibits dose-dependent enzyme-based microsomal aromatase inhibitory activity. Garcinone D inhibits p65 acti... | |||
TN3069 | 4beta-Carboxy-19-nortotarol | NADPH-oxidase | |
4 beta-Carboxy-19-nortotarol can inhibit microsomal lipid peroxidation induced by Fe(III)-ADP/NADPH and mitochondrial lipid peroxidation induced by Fe(III)-ADP/ NADH, it inhibits linoleic acid autoxidation but not genera... | |||
T37972 | 12-OxoETE | ||
12-OxoETE is synthesized by human platelets and Aplysia nervous tissue after incubation with arachidonic acid. Microsomal fractions of various tissues will reduce 12-oxoETE to 12(S)-HETE or a mixture of 12(S)- and 12(R)-... |
Cat No. | Product Name | Species | Expression System |
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TMPJ-00723 | CYB5A Protein, Human, Recombinant (His) | Human | E. coli |
Cytochrome b5 (CYB5A) is a membrane bound hemoprotein which function as an electron carrier for several membrane bound oxygenases. CYB5A contains one cytochrome b5 heme-binding domain and has two isoforms produced by alt... | |||
TMPH-03099 | Aminopeptidase N/CD13 Protein, Pig, Recombinant (His & Myc) | Sus scrofa (Pig) | E. coli |
Broad specificity aminopeptidase which plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. Also involved in the processing of various peptides includ... | |||
TMPY-02779 | Thyroid peroxidase Protein, Human, Recombinant (S257A & P725T, His) | Human | Baculovirus-Insect Cells |
Thyroid peroxidase is a membrane-bound glycoprotein which belongs to the peroxidase family, XPO subfamily. It contains 1 EGF-like domain and 1 Sushi (CCP/SCR) domain. Thyroid Peroxidase represents one of the main autoant... | |||
TMPY-00989 | LDLR Protein, Human, Recombinant (His) | Human | HEK293 |
LDL Receptor, also known as LDLR, is a mosaic protein that belongs to the Low-density lipoprotein receptor gene family. The low-density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved i... | |||
TMPY-01012 | P4HB Protein, Human, Recombinant (His) | Human | HEK293 |
Protein disulfide-isomerase, also known as Cellular thyroid hormone-binding protein, Prolyl 4-hydroxylase subunit beta, p55 and P4HB, is a peripheral membrane protein that belongs to the protein disulfide isomerase famil... | |||
TMPH-02110 | SEC11C Protein, Human, Recombinant (His & SUMO) | Human | E. coli |
Component of the microsomal signal peptidase complex which removes signal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. | |||
TMPH-01780 | SCP2 Protein, Human, Recombinant (GST) | Human | E. coli |
Plays a crucial role in the peroxisomal oxidation of branched-chain fatty acids. Catalyzes the last step of the peroxisomal beta-oxidation of branched chain fatty acids and the side chain of the bile acid intermediates d... | |||
TMPY-05499 | LDLR Protein, Human, Recombinant (His), Biotinylated | Human | HEK293 |
LDL Receptor, also known as LDLR, is a mosaic protein that belongs to the Low-density lipoprotein receptor gene family. The low-density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved i... | |||
TMPY-01014 | LDLR Protein, Mouse, Recombinant (His) | Mouse | HEK293 |
LDL Receptor, also known as LDLR, is a mosaic protein that belongs to the Low-density lipoprotein receptor gene family. The low-density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved i... | |||
TMPY-05323 | LDLR Protein, Human, Recombinant (mFc) | Human | HEK293 |
LDL Receptor, also known as LDLR, is a mosaic protein that belongs to the Low-density lipoprotein receptor gene family. The low-density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved i... | |||
TMPY-05809 | LDLR Protein, Human, Recombinant (193D/A, His) | Human | HEK293 |
LDL Receptor, also known as LDLR, is a mosaic protein that belongs to the Low-density lipoprotein receptor gene family. The low-density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved i... | |||
TMPY-05348 | LDLR Protein, Mouse, Recombinant (His), Biotinylated | Mouse | HEK293 |
LDL Receptor, also known as LDLR, is a mosaic protein that belongs to the Low-density lipoprotein receptor gene family. The low-density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved i... | |||
TMPY-01795 | P4HB Protein, Mouse, Recombinant (His) | Mouse | HEK293 |
Protein disulfide-isomerase, also known as Cellular thyroid hormone-binding protein, Prolyl 4-hydroxylase subunit beta, p55 and P4HB, is a peripheral membrane protein that belongs to the protein disulfide isomerase famil... |