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Search Results for " microsomal "

Targets

69

Compounds

5

Natural Products

13

Recombinant Proteins

Cat No. Product Name Synonyms Targets
T27719 KD-026 SLx 4090,SLx4090,KD026,SLx-4090 CETP
KD-026 (SLx 4090), a microsomal triglyceride transfer protein (MTP) inhibitor(IC50 = 8.0 nM), is used in type 2 diabetes studies.
T20625 Prochloraz Sporgon,Prelude Estrogen Receptor/ERR , AhR , Androgen Receptor , Antifungal
Prochloraz (Prelude) is a broad-spectrum contact imidazole fungicide. Prochloraz inhibits human placental microsomal aromatase in vitro (IC50 = 40 nM). Prochloraz also acts as an estrogen receptor (IC50s = 25 μM) and and...
T23861 CAY10526 CAY-10526,BTH,CAY 10526 Prostaglandin Receptor
CAY10526 (BTH) is a selective mPGES-1 inhibitor that acts as an inhibitor of the NF-κB signaling pathway.
T12856 SC-26196 Others
SC-26196 is an orally active inhibitor of Delta6 desaturase (D6D) with IC50 of 0.2 µM in a rat liver microsomal assay, with antiinflammatory properties.
T2545 Lomitapide Mesylate BMS-201038 mesylate,AEGR-733 mesylate CETP
Lomitapide Mesylate (BMS-201038 mesylate) is a methanesulfonic acid form of lomitapide, a small molecule inhibitor of microsomal triglyceride transfer protein.
T16928 SR144528 Cannabinoid Receptor
SR144528 is an antagonist of the CB2 receptor (Ki = 0.6 nM) and inhibits microsomal ACAT activity (IC50 = 3.6 μM).
T14523 Beauvericin Others , Acyltransferase
Beauvericin, a Fusarium mycotoxin, inhibits acyl-CoA:cholesterol acyltransferase (ACAT) in rat liver microsomal enzyme assays with an IC50 value of 3 μM.
T28089 MPGES-1 Inhibitor-1 Prostaglandin Receptor
mPGES-1 Inhibitor-1 is a novel selective inhibitor of microsomal prostaglandin E synthase-1 (mPGES-1) with anti-inflammatory and analgesic activity for the study of acute liver injury.
T27084 Crisdesalazine AAD2004,AAD 2004,AAD-2004 Prostaglandin Receptor
Crisdesalazine (AAD 2004) is an inhibitor of microsomal prostaglandin E2 synthase-1 (mPGES-1). Crisdesalazine reduces autophagosome formation, axonopathy, and motor neuron degeneration, improving motor function and incre...
T30506 BMS-212122 UNII-0Z473OO6GB,BMS212122,BMS 212122 CETP
BMS-212122 (UNII-0Z473OO6GB) is a potent inhibitor of microsomal triglyceride transfer protein (MTP) and has shown hypolipidemic effects in animal studies.BMS-212122 significantly reduced lipid content and monocyte-deriv...
T16865 SCH28080 ATPase , Proton pump
SCH28080 is a reversible and K+-competitive inhibitor of gastric H+/K+-ATPase with an IC50 value of 20 nM (rabbit microsomal membrane).SCH28080 is a potent inhibitor of acid secretion in vivo with anti-ulcer activity, an...
T15006 Dirlotapide CP742033,Slentrol Others , CETP
Dirlotapide (CP742033) is an intestinal selective microsomal triglyceride transfer protein (MTP) inhibitor. It reduces body weight in diabetic dogs.Dirlotapide reduces food intake in a dose-dependent manner, possibly by ...
T31992 Granotapide CETP
Granotapide is a microsomal triglyceride transfer protein (MTP) inhibitor that treats and rather prevents atherosclerosis, coronary artery disease, metabolic syndrome, obesity, diabetes mellitus, prediabetes mellitus, an...
T21738 PF-9184 Prostaglandin Receptor
PF-9184 is a potent and selective inhibitor of human microsomal prostaglandin E synthase-1 (mPGES-1), IC50 =16.5 nM. PF-9184 inhibits IL-1β-induced PGE2 synthesis in vitro.
T6267 Lomitapide AEGR-733,BMS-201038 CETP
Lomitapide (AEGR-733) is a small molecule inhibitor of microsomal triglyceride transfer protein (MTP), an enzyme located in the lumen of the endoplasmic reticulum responsible for absorbing dietary lipids and transferring...
T37825 CAY10434 P450
CAY10434 is an active inhibitor of CYP4A hydroxylase with an IC50 value of 8.8 nM in human kidney microsomal test. The maximum contractile value (Emax) of CAY 10434 was 6764 mg in improving the contractile process of ang...
T1055 Ifosfamide NSC109724,Isophosphamide DNA Alkylator/Crosslinker , DNA/RNA Synthesis
Ifosfamide (NSC-109724) alkylates and forms DNA crosslinks, thereby preventing DNA strand separation and DNA replication. Ifosfamide is a synthetic analog of the nitrogen mustard cyclophosphamide with antineoplastic acti...
T9394 CHIKV-IN-2 Dehydrogenase
CHIKV-IN-2, a chemical compound, exhibits potent inhibitory activity against the enzyme Dihydroorotate Dehydrogenase (DHODH), crucial for pyrimidine synthesis affecting various viruses' replication. It serves as an effec...
T72470 Estrone O-sulfamate Estrone 3-O-sulfamate Others
Estrone O-sulfamate (Estrone 3-O-sulfamate) is a potent inhibitor of steroid sulfatase (STS). Estrone O-sulfamate is a placental microsomal inhibitor (P.M.) with IC50 values of 18 nM. Estrone O-sulfamate showed inhibitor...
T35610 2,5-dimethyl Celecoxib Apoptosis , Wnt/beta-catenin , Prostaglandin Receptor
2,5-dimethyl Celecoxib is a derivative of celecoxib that does not inhibit COX-2 (IC50 = >100 μM).1 It does inhibit microsomal prostaglandin E synthase-1 (mPGES-1) in HeLa cells (IC50 = 15.6 μM) and reduces prostaglandin ...
T36696 DMBA
7,12-Dimethylbenz[a]anthracene (DMBA) is a polycyclic aromatic hydrocarbon (PAH) that has been found in tobacco smoke and diesel exhaust and has carcinogenic activity.1,2It undergoes metabolic activation by numerous enzy...
T6412 CVT-12012 Stearoyl-CoA Desaturase (SCD)
CVT-12012 is an orally bioavailable inhibitor of stearoyl-CoA desaturase (SCD; IC50 = 6.1 nM in HepG2 cells).
T12765 RPR107393 free base Others
RPR107393 free base is a selective inhibitor of squalene synthase(rat liver microsomal squalene synthase, with an IC50 of 0.8 nM).
T33110 M 79193 M79193,M-79193
M 79193 induces total hepatic microsomal cytochrome P-450.
T13418 CP-319340(free base) Others
CP-319340 free base is a inhibitor of microsomal triglyceride transfer protein (MTP) .
T24223 JTT 130 JTT-130,JTT130
JTT 130 is an agent of hypolipidemic. It inhibits microsomal triglyceride transfer protein.
T15570 Implitapide AEGR 427 CETP
Implitapide is an inhibitor of microsomal triglyceride transfer protein (MTP).
T25440 FR20 FR-20,FR 20
FR20 is a human microsomal prostaglandin synthase 1 (mPGES 1) inhibitor.
T16158 PF-02575799 Adenosine Receptor
PF-02575799 is an inhibitor of microsomal triglyceride transfer protein (MTP) (IC50: 0.77±0.29 nM).
T10504 Implitapide Racemate Others
Implitapide Racemate is the racemate of Implitapide. Implitapide is an inhibitor of microsomal triglyceride transfer protein (MTP).
T12100 MPGES1-IN-3 Prostaglandin Receptor
mPGES1-IN-3 is a potent and selective inhibitor of microsomal prostaglandin E2 synthase-1 (mPGES-1) .
T35005 Usistapide R-256918,JNJ-16269110,JNJ16269110,R256918,JNJ 16269110,R 256918
UsISpide(JNJ-16269110 R256918) is an inhibitor of microsomal triglyceride transfer protein (MTTP) under development for the treatment of obesity and type 2 diabetes.
T23596 A-933548 A933548,A 933548
A-933548 is a potent Calpain inhibitor. A-933548 features enhanced selectivity versus related cysteine protease cathepsins, favorable microsomal stability, and efficacy in cellular assays.
T16504 PF-4693627 Prostaglandin Receptor
PF-4693627 is an effective and selective microsomal prostaglandin E synthase-1 inhibitor (IC50=3 nM). It is used for the treatment of inflammation caused by osteoarthritis (OA) and rheumatoid arthritis (RA).
T23598 A-953227 A 953227,A953227
A-953227 is a highly effective and selective inhibitor of calpain. A-953227 features enhanced selectivity versus related cysteine protease cathepsins, favorable microsomal stability, and efficacy in cellular assays.
T14564 BI-4924 Others
BI-4924 is an inhibitor of phosphoglycerate dehydrogenase (PHGDH) (IC50=3 nM). It has excellent Microsomal and hepatocytic stability. Intracellular trapping of BI-4924 disrupts serine biosynthesis at 72 h ( IC50: 2200 nM...
T68375 KD026-metabolite
KD026-metabolite, is a metabolite of KD-026. KD026, also known as SLx-4090, is a microsomal triglyceride transfer protein (MTTP) inhibitor potentially for the treatment of type 2 diabetes.
T38666 CP-346086 dihydrate
CP-346086 dihydrate is a potent and orally active inhibitor of microsomal triglyceride transfer protein (MTP), exhibiting an IC50 value of 2.0 nM for both human and rodent MTP. This compound effectively lowers plasma cho...
T39000 Zaloglanstat GRC-27864,ISC-27864
Zaloglanstat (ISC-27864) is a potent inhibitor of microsomal prostaglandin E synthase-1 (mPGES-1). It is utilized in the research of various conditions, including asthma, osteoarthritis, rheumatoid arthritis, acute or ch...
T39303 CP-346086
CP-346086 is a highly potent and orally bioavailable inhibitor of microsomal triglyceride transfer protein (MTP), exhibiting an IC50 value of 2.0 nM against both human and rodent MTP. This compound effectively reduces pl...
T61504 PKM2 activator 3
PKM2 activator 3 is a highly potent compound that activates PKM2, with an AC 50 value of 90 nM. It exhibits excellent Caco-2 permeability, a low efflux ratio, and remarkable microsomal stability. PKM2 activator 3 is part...
T37840 20-hydroxy Prostaglandin F2α 20-hydroxy Prostaglandin F2α
20-hydroxy Prostaglandin F2α (20-hydroxy PGF2α) is the ω-oxidation product of PGF2α. Cultured type II alveolar cells from pregnant rabbits metabolize exogenous PGF2α via microsomal cytochrome P450 ω-oxidation, producing ...
T38143 Elaidamide
Elaidamide is a fatty acid amide that has been found in the cerebrospinal fluid of sleep-deprived cats.1 It inhibits rat microsomal epoxide hydrolase (mEH; Ki = 70 nM).2 Elaidamide also inhibits porcine pancreatic and hu...
T62850 IRAK4-IN-13
IRAK4-IN-13 (compound 21) is a selective and potent IRAK4 inhibitor (IC50: 0.6 nM). iRAK4-IN-13 has a high metabolic clearance, with an intrinsic human liver microsomal (HLM) clearance of 96 μL/min/mg.
T74520 TD-802
TD-802 (Compound 33c), an androgen receptor (AR) PROTAC degrader, exhibits strong microsomal stability and demonstrates potent antitumor efficacy in vivo, making it suitable for research on metastatic castration-resistan...
T60346 PDE4-IN-10
PDE4-IN-10 (compound 7a) is a potent inhibitor of PDE4, with an IC 50 of 7.01 μM for PDE4B. PDE4-IN-10 exhibits selectivity, microsomal stability, inhibition of TNF-α and no major toxicities in vitro [1].
T74781 UT-11
UT-11 is a potent brain-permeable inhibitor of microsomal prostaglandin E synthase-1 (mPGES-1), exhibiting IC50 values of 0.10 μM and 2.00 μM for the inhibition of PGE2 production in human (SK-N-AS) and murine (BV2) cell...
T83187 AChE-IN-41
AChE-IN-41 (Compound 2), a Galantamine-Memantine hybrid, possesses cholinesterase inhibitory capabilities. This compound demonstrates enhanced plasma stability and similar microsomal stability in vitro but has a reduced ...
T79272 BDM91514
BDM91514 enhances antibiotic efficacy by inhibiting AcrB, effectively curbing the proliferation of E. coli BW25113 with an EC90 of 8 μM when coupled with 8 μg/mL Pyridomycin. Additionally, BDM91514 exhibits favorable pla...
T79440 DprE1-IN-5
DprE1-IN-5 (Compound 10), a potent DprE1 inhibitor, exhibits anti-TB activity with an MIC of 4 μM against the Mtb H37Rv strain and demonstrates antimycobacterial efficacy against drug-resistant strains. Additionally, it ...

Compounds

KD-026
T27719
Synonym: SLx 4090,SLx4090,KD026,SLx-4090
Target: CETP
Prochloraz
T20625
Synonym: Sporgon,Prelude
Target: Estrogen Receptor/ERR, AhR, Androgen Receptor, Antifungal
CAY10526
T23861
Synonym: CAY-10526,BTH,CAY 10526
Target: Prostaglandin Receptor
SC-26196
T12856
Synonym:
Target: Others
Lomitapide Mesylate
T2545
Synonym: BMS-201038 mesylate,AEGR-733 mesylate
Target: CETP
SR144528
T16928
Synonym:
Target: Cannabinoid Receptor
Beauvericin
T14523
Synonym:
Target: Others, Acyltransferase
mPGES-1 Inhibitor-1
T28089
Synonym:
Target: Prostaglandin Receptor
Crisdesalazine
T27084
Synonym: AAD2004,AAD 2004,AAD-2004
Target: Prostaglandin Receptor
BMS-212122
T30506
Synonym: UNII-0Z473OO6GB,BMS212122,BMS 212122
Target: CETP
SCH28080
T16865
Synonym:
Target: ATPase, Proton pump
Dirlotapide
T15006
Synonym: CP742033,Slentrol
Target: Others, CETP
Granotapide
T31992
Synonym:
Target: CETP
PF-9184
T21738
Synonym:
Target: Prostaglandin Receptor
Lomitapide
T6267
Synonym: AEGR-733,BMS-201038
Target: CETP
CAY10434
T37825
Synonym:
Target: P450
Ifosfamide
T1055
Synonym: NSC109724,Isophosphamide
Target: DNA Alkylator/Crosslinker, DNA/RNA Synthesis
CHIKV-IN-2
T9394
Synonym:
Target: Dehydrogenase
Estrone O-sulfamate
T72470
Synonym: Estrone 3-O-sulfamate
Target: Others
2,5-dimethyl Celecoxib
T35610
Synonym:
Target: Apoptosis, Wnt/beta-catenin, Prostaglandin Receptor
DMBA
T36696
Synonym:
Target:
CVT-12012
T6412
Synonym:
Target: Stearoyl-CoA Desaturase (SCD)
RPR107393 free base
T12765
Synonym:
Target: Others
M 79193
T33110
Synonym: M79193,M-79193
Target:
CP-319340(free base)
T13418
Synonym:
Target: Others
JTT 130
T24223
Synonym: JTT-130,JTT130
Target:
Implitapide
T15570
Synonym: AEGR 427
Target: CETP
FR20
T25440
Synonym: FR-20,FR 20
Target:
PF-02575799
T16158
Synonym:
Target: Adenosine Receptor
Implitapide Racemate
T10504
Synonym:
Target: Others
mPGES1-IN-3
T12100
Synonym:
Target: Prostaglandin Receptor
Usistapide
T35005
Synonym: R-256918,JNJ-16269110,JNJ16269110,R256918,JNJ 16269110,R 256918
Target:
A-933548
T23596
Synonym: A933548,A 933548
Target:
PF-4693627
T16504
Synonym:
Target: Prostaglandin Receptor
A-953227
T23598
Synonym: A 953227,A953227
Target:
BI-4924
T14564
Synonym:
Target: Others
KD026-metabolite
T68375
Synonym:
Target:
CP-346086 dihydrate
T38666
Synonym:
Target:
Zaloglanstat
T39000
Synonym: GRC-27864,ISC-27864
Target:
CP-346086
T39303
Synonym:
Target:
PKM2 activator 3
T61504
Synonym:
Target:
20-hydroxy Prostaglandin F2α
T37840
Synonym: 20-hydroxy Prostaglandin F2α
Target:
Elaidamide
T38143
Synonym:
Target:
IRAK4-IN-13
T62850
Synonym:
Target:
TD-802
T74520
Synonym:
Target:
PDE4-IN-10
T60346
Synonym:
Target:
UT-11
T74781
Synonym:
Target:
AChE-IN-41
T83187
Synonym:
Target:
BDM91514
T79272
Synonym:
Target:
DprE1-IN-5
T79440
Synonym:
Target:
1 2
Cat No. Product Name Synonyms Targets
T5261 (E)-Oct-2-enoic acid trans-2-Octenoic acid,2-Octenoate,2-Octenoic acid Others , Endogenous Metabolite
(E)-Oct-2-enoic acid (2-Octenoate) is a normal organic acid produced by hepatic microsomal oxidation of aliphatic aldehydes and is a metabolite naturally found in the urine and plasma.
TN1818 Kaempferol 3-O-β-D-glucuronide Kaempferol-3-O-glucuronide,Kaempferol-3-beta-O-glucuronide,Kaempferol-3-glucuronide IL Receptor
Kaempferol 3-O-β-D-glucuronide (Kaempferol-3-beta-O-glucuronide)e has antioxidant activity. Flavonoid glucuronides can be deconjugated by microsomal α²-glucuronidase from various human cells.
TN1674 Garcinone D Reactive Oxygen Species , Nrf2 , STAT
Garcinone D shows significant cytotoxicity against the CEM-SS cell line, with IC(50) value of 3.2 microg/ml; it exhibits dose-dependent enzyme-based microsomal aromatase inhibitory activity. Garcinone D inhibits p65 acti...
TN3069 4beta-Carboxy-19-nortotarol NADPH-oxidase
4 beta-Carboxy-19-nortotarol can inhibit microsomal lipid peroxidation induced by Fe(III)-ADP/NADPH and mitochondrial lipid peroxidation induced by Fe(III)-ADP/ NADH, it inhibits linoleic acid autoxidation but not genera...
T37972 12-OxoETE
12-OxoETE is synthesized by human platelets and Aplysia nervous tissue after incubation with arachidonic acid. Microsomal fractions of various tissues will reduce 12-oxoETE to 12(S)-HETE or a mixture of 12(S)- and 12(R)-...

Recombinant Proteins

Cat No. Product Name Species Expression System
TMPJ-00723 CYB5A Protein, Human, Recombinant (His) Human E. coli
Cytochrome b5 (CYB5A) is a membrane bound hemoprotein which function as an electron carrier for several membrane bound oxygenases. CYB5A contains one cytochrome b5 heme-binding domain and has two isoforms produced by alt...
TMPH-03099 Aminopeptidase N/CD13 Protein, Pig, Recombinant (His & Myc) Sus scrofa (Pig) E. coli
Broad specificity aminopeptidase which plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. Also involved in the processing of various peptides includ...
TMPY-02779 Thyroid peroxidase Protein, Human, Recombinant (S257A & P725T, His) Human Baculovirus-Insect Cells
Thyroid peroxidase is a membrane-bound glycoprotein which belongs to the peroxidase family, XPO subfamily. It contains 1 EGF-like domain and 1 Sushi (CCP/SCR) domain. Thyroid Peroxidase represents one of the main autoant...
TMPY-00989 LDLR Protein, Human, Recombinant (His) Human HEK293
LDL Receptor, also known as LDLR, is a mosaic protein that belongs to the Low-density lipoprotein receptor gene family. The low-density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved i...
TMPY-01012 P4HB Protein, Human, Recombinant (His) Human HEK293
Protein disulfide-isomerase, also known as Cellular thyroid hormone-binding protein, Prolyl 4-hydroxylase subunit beta, p55 and P4HB, is a peripheral membrane protein that belongs to the protein disulfide isomerase famil...
TMPH-02110 SEC11C Protein, Human, Recombinant (His & SUMO) Human E. coli
Component of the microsomal signal peptidase complex which removes signal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum.
TMPH-01780 SCP2 Protein, Human, Recombinant (GST) Human E. coli
Plays a crucial role in the peroxisomal oxidation of branched-chain fatty acids. Catalyzes the last step of the peroxisomal beta-oxidation of branched chain fatty acids and the side chain of the bile acid intermediates d...
TMPY-05499 LDLR Protein, Human, Recombinant (His), Biotinylated Human HEK293
LDL Receptor, also known as LDLR, is a mosaic protein that belongs to the Low-density lipoprotein receptor gene family. The low-density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved i...
TMPY-01014 LDLR Protein, Mouse, Recombinant (His) Mouse HEK293
LDL Receptor, also known as LDLR, is a mosaic protein that belongs to the Low-density lipoprotein receptor gene family. The low-density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved i...
TMPY-05323 LDLR Protein, Human, Recombinant (mFc) Human HEK293
LDL Receptor, also known as LDLR, is a mosaic protein that belongs to the Low-density lipoprotein receptor gene family. The low-density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved i...
TMPY-05809 LDLR Protein, Human, Recombinant (193D/A, His) Human HEK293
LDL Receptor, also known as LDLR, is a mosaic protein that belongs to the Low-density lipoprotein receptor gene family. The low-density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved i...
TMPY-05348 LDLR Protein, Mouse, Recombinant (His), Biotinylated Mouse HEK293
LDL Receptor, also known as LDLR, is a mosaic protein that belongs to the Low-density lipoprotein receptor gene family. The low-density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved i...
TMPY-01795 P4HB Protein, Mouse, Recombinant (His) Mouse HEK293
Protein disulfide-isomerase, also known as Cellular thyroid hormone-binding protein, Prolyl 4-hydroxylase subunit beta, p55 and P4HB, is a peripheral membrane protein that belongs to the protein disulfide isomerase famil...
TargetMol