mertk

Expression system: HEK293 Cells
Length: 1-323, Partial
Activity: Not Tested

Expression system: HEK293 Cells
Length: 21-505, Partial
Activity: Not Tested

Expression system: HEK293 Cells
Length: 21-505, Partial
Activity: Not Tested

Expression system: HEK293 Cells
Length: 19-497, Partial
Activity: Not Tested

MERTK Mer Protein, Rat, Recombinant (His) is expressed in Mammalian cell. The accession number is P57097.

ACK1 (also known as ACK, TNK2, or activated Cdc42 kinase) is a structurally unique non-receptor tyrosine kinase that is expressed in diverse cell types. This downstream effector of CDC42 mediates CDC42-dependent cell migration via phosphorylation of BCAR1. The ACK1 protein may be involved in a regulatory mechanism that sustains the GTP-bound active form of Cdc42Hs and which is directly linked to a tyrosine phosphorylation signal transduction pathway. ACK1 integrates signals from plethora of ligand-activated receptor tyrosine kinases (RTKs), for example, MERTK, EGFR, HER2 and PDGFR to initiate intracellular signaling cascades. It binds to both poly- and mono-ubiquitin and regulates ligand-induced degradation of EGFR. ACK1 transduces extracellular signals to cytosolic and nuclear effectors such as the protein kinase AKT PKB and androgen receptor (AR), to promote cell survival and growth. ACK1 participates in tumorigenesis, cell survival, and migration. Gene amplification and overexpression of ACK1 were found in many cancer types such as those of the lung and prostate. Recently, four somatic missense mutations of ACK1, which occur in the N-terminal region, the C-lobe of the kinase domain, and the SH3 domain, were identified in cancer tissue samples.

Expression system: HEK293 Cells
Length: 1-674, Full Length
Activity: Not Tested