marcks

BIO-11006 acetate salt (901117-03-1 free base) is a polyglycosylated alanine rich C kinase substrate (MARCKS) inhibitor similar to MANS peptides.

Myristoylated Alanine-Rich C Kinase Substrate peptide (151-175) is a high affinity Protein Kinase C substrate.

MPSD (MARCKS-ED), a 25-amino acid peptide derived from the effector domain sequence of the myristoylated alanine-rich C-kinase substrate (MARCKS), possesses the ability to detect membrane curvature and identify phosphatidylserine. This compound is valuable as a biological probe for investigating membrane shape and lipid composition.

MPSDTFA (MARCKS-ED TFA) is the TFA salt form of MPSD. This compound is a peptide consisting of 25 amino acid residues derived from the effector domain sequence of the endoplasmic reticulum protein myristoylated alanine-rich C-kinase substrate (MARCKS). MPSD TFA is capable of sensing membrane curvature and recognizing phosphatidylserine. It serves as a biological probe for studying membrane morphology and lipid composition.

MPSDcontrol peptide (MARCKS-ED control peptide) TFA serves as the control peptide for MPSD. MPSD (MARCKS-ED) is a 25-amino acid peptide derived from the effector domain sequence of MARCKS, a myristoylated alanine-rich C kinase substrate, which is an intracellular membrane protein.

MPSDcontrol peptide (MARCKS-ED control peptide) serves as the counterpart for the MPSD peptide. MPSD (MARCKS-ED) is a 25-amino acid residue peptide derived from the effector domain sequence of the endoplasmic reticulum protein MARCKS. It can detect membrane curvature and identify phosphatidylserine, functioning as a biological probe for examining membrane morphology and lipid composition.

Isosaponarin is a natural product with multiple activities. It inhibits the increase in Ca2+ levels induced by 4-aminopyridine in rat synaptosomes without affecting the membrane potential of synaptosomes, while reducing the phosphorylation of PKC, PKCα, SNAP-25, and MARCKS, thereby inhibiting the release of glutamate from vesicles in synaptosomes.

H-1152 is a cell membrane-permeable and selective ROCK (Rho-kinase) inhibitor (Ki=1.6 nM) that increases neurite length in neuron-rich cultures and inhibits MARCKS Ser159 phosphorylation in LPA-stimulated neuronal cells.

PKCε (85-92) (ψεRACK) is a peptide and selective PKCε activator that does not affect the activity of other PKC isozymes.PKCε (85-92) induces a pro-angiogenic response in endothelial cells, promotes FGF-2 cytosolization, and regulates VEGF activity.

Epsilon-V1-2, a Cys-conjugated, is a biologically active peptide known as the εPKC-specific inhibitor. It hampers εPKC functionality by obstructing its translocation and the phosphorylation of MARCKS, additionally perturbing εPKC's interaction with its anchoring protein, εRACK. The peptide includes a cysteine residue at its C-terminus, facilitating the formation of potential disulfide bonds with carrier proteins. Pyroglutamyl formation can occur spontaneously at the N-terminus if glutamine or glutamic acid is present, enhancing peptide stability against gastrointestinal proteases. Pyroglutamyl peptides, a recognized subset, are accounted for in the peptide's purity during HPLC analysis.

MANS peptide inhibits myristoylated alanine-rich C kinase substrate (MARCKS) by competing for membrane binding in cells, thereby inhibiting mucin secretion stimulation and tumor metastasis [1].

BIO-11006 Inhibitor is a nebulized 10-amino acid peptide compound that inhibits the protein kinase C substrate known as myristoylated alanine-rich C-kinase substrate (MARCKS) protein, offering potential immunoregulatory and antitumor activities.