maleimide peg4 nhs

Maleimide-PEG4-NHS is a sulfhydryl and amine reactive heterofuncational PEG linker. The chemical bonds formed through Maleimide-PEG4-NHS linker are stable and are not cleavable. The NHS ester reacts with amino groups at pH 7-9 to form stable amide bond wh

Mal-PEG4-NHS ester is a noncleavable ADC linker with a Maleimide group, a 4-unit PEG, and an NHS ester.

Mal-PEG4-amine, a PEG linker containing a maleimide group and an amine group, features a hydrophilic PEG spacer that enhances its solubility in aqueous media. The amine group can react with carboxylic acids, activated NHS esters, and carbonyls (ketones, aldehydes). The maleimide group reacts with thiol groups to form covalent bonds, enabling the conjugation of biomolecules with thiols.