l002

L002, a potent, cell-permeable, reversible, and specific acetyltransferase p300 (KAT3B) inhibitor with an IC50 of 1.98 μM, directly binds the acetyl-CoA pocket and competitively inhibits the FATp300 catalytic domain. By blocking histone acetylation, p53 acetylation, and STAT3 activation, L002 shows potential in the treatment of hypertension‐induced cardiac hypertrophy and fibrogenesis.

OG-L002 is an effective and selective LSD1 inhibitor (IC50: 20 nM), showing 69- and 36-fold selectivity over MAO-A and MAO-B, respectively.

OG-L002 hydrochloride is an effective and highly selective inhibitor of LSD1, with an IC50 of 0.02 µM. Additionally, it serves as an efficient monoamine oxidase (MAO) inhibitor, exhibiting IC50 values of 1.38 µM for MAO-A and 0.72 µM for MAO-B. This compound also effectively suppresses the expression of the HSV1E gene.

Compound FL0023, with CAS No. 744183-20-8, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. Compound FL0023 provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

Compound FL0024, with CAS No. 132234-69-6, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. Compound FL0024 provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

Compound FL0025, with CAS No. 56842-95-6, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. Compound FL0025 provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

Compound FL0027, with CAS No. 180464-87-3, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. Compound FL0027 provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

DL002 is an ADC linker used to synthesize antibody-drug conjugates that incorporate BCL-2 family protein degraders, intended for cancer research applications.

AL002 is a humanized monoclonal immunoglobulin G1 (IgG1) antibody and acts as a TREM2 agonist antibody, suitable for research in neurological disorders.

MCL0020 is a potent and selective melanocortin MC4 receptor antagonist (IC50 values are 11.63, 1115, and >10,000 nM at MC4, MC3, and MC1 receptors, respectively). It significantly reverses stress-induced anorexia without affecting food intake in free-feeding rats and exhibits anxiolytic-like activity in vivo.