l002

L002, a potent, cell-permeable, reversible, and specific acetyltransferase p300 (KAT3B) inhibitor with an IC50 of 1.98 μM, directly binds the acetyl-CoA pocket and competitively inhibits the FATp300 catalytic domain. By blocking histone acetylation, p53 acetylation, and STAT3 activation, L002 shows potential in the treatment of hypertension‐induced cardiac hypertrophy and fibrogenesis.

OG-L002 is an effective and selective LSD1 inhibitor (IC50: 20 nM), showing 69- and 36-fold selectivity over MAO-A and MAO-B, respectively.

OG-L002 hydrochloride is an effective and highly selective inhibitor of LSD1, with an IC50 of 0.02 µM. Additionally, it serves as an efficient monoamine oxidase (MAO) inhibitor, exhibiting IC50 values of 1.38 µM for MAO-A and 0.72 µM for MAO-B. This compound also effectively suppresses the expression of the HSV1E gene.

Compound FL0028, with CAS No. 1630906-99-8, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. Compound FL0028 provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

DL002 is an ADC linker used to synthesize antibody-drug conjugates that incorporate BCL-2 family protein degraders, intended for cancer research applications.

AL002 is a humanized monoclonal immunoglobulin G1 (IgG1) antibody and acts as a TREM2 agonist antibody, suitable for research in neurological disorders.

MCL0020 is a potent and selective melanocortin MC4 receptor antagonist (IC50 values are 11.63, 1115, and >10,000 nM at MC4, MC3, and MC1 receptors, respectively). It significantly reverses stress-induced anorexia without affecting food intake in free-feeding rats and exhibits anxiolytic-like activity in vivo.

N-Boc-exo-3-Aminotropane ,with CAS No. 744183-20-8, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. N-Boc-exo-3-Aminotropane provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

Endo-3-Boc-Aminotropane ,with CAS No. 132234-69-6, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. Endo-3-Boc-Aminotropane provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

Bicyclo[1.1.1]pentane-1,3-dicarboxylic acid ,with CAS No. 56842-95-6, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. Bicyclo[1.1.1]pentane-1,3-dicarboxylic acid provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

Bicyclo[1.1.1]pentane-1-carboxylic acid, 3-(hydroxymethyl)-, methyl ester (9ci) ,with CAS No. 180464-87-3, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. Bicyclo[1.1.1]pentane-1-carboxylic acid, 3-(hydroxymethyl)-, methyl ester (9ci) provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

ML-00253764 hydrochloride is an antagonist of nonpeptidic melanocortin receptor 4 (MC4R) (Ki and IC50 of 0.16 µM and 0.103 µM, respectively).

melanocortin MC4 receptor antagonist

Visugromab (CTL-002) is a monoclonal antibody that targets and neutralises GDF-15. Visugromab exhibits synergistic anticancer activity with the anti-PD1 antibody Nivolumab, making it suitable for PD-1/PD-L1 recurrent/refractory metastatic solid tumours.

BAL-0028 is a potent inhibitor of NLRP3 activation (IC50: 25 nM) with anti-inflammatory activity for cancer research.

Methyl melissate is an organic compound commonly used as a fragrance and food additive. It is utilized in the formulation of various flavor extracts and food seasonings, with widespread applications in food, fragrances, and cosmetics. Additionally, this compound serves as a substrate or intermediate in certain biochemical reactions.

Methyl 15-methylhexadecanoate is a biochemical reagent that can be used as a biomaterial for life science related research and as a sulfonylation reagent for organic synthesis and drug discovery.

Heptadecan-9-yl 8-((2-hydroxyethyl)amino)octanoate is a lipid utilized in compound synthesis.

DOP-DEDA is a reagent used in biochemical reactions.

Doconexent sodium is a biochemical reagent that can be used as a biomaterial for life science related research and as a sulfonylation reagent for organic synthesis and drug discovery.

Methyl 12-aminododecanoate hydrochloride is a biochemical reagent that can be used as a biomaterial for life science related research and as a sulfonylation reagent for organic synthesis and drug discovery.

DOTAP mesylate is a biochemical reagent that can be used as a biomaterial for life science related research and as a sulfonylation reagent for organic synthesis and drug discovery.

Trimethyl[2,3-(dioleyloxy)propyl]ammonium chloride is a biochemical reagent that can be used as a biomaterial for life science related research and as a sulfonylation reagent for organic synthesis and drug discovery.

DOTAP methylsulfat is a cationic lipid reagent derived from trimethylammonium, featuring two 18-carbon fatty acid tails each with a single alkene group. This compound can self-assemble with negatively charged ions (such as DNA) to form complexes that adhere to cell membranes and enter cells through electrostatic interactions and endocytosis. With its hydrophobic domains, DOTAP methylsulfat facilitates the fusion of endosomal membranes to release DNA into the cytoplasm, serving a role in gene delivery. It is widely used in research areas like gene therapy, cell transfection, and the design of non-viral vectors.