klebsiella pneumonia

Avibactam sodium (NXL-104) is a non-β-lactam β-lactamase inhibitor that inhibits TEM-1, P99, and KPC-2 β-lactamases (IC50=8/80/38 nM) covalently and reversibly. Avibactam sodium has antimicrobial activity and can be used to treat urinary tract infections.

Lipopolysaccharides from Klebsiella pneumoniae (LPS, from bacterial [Klebsiella pneumoniae]) are lipid-polysaccharide endotoxins and TLR4 activators originating from Klebsiella pneumoniae, classified as S-type LPS. They exhibit a characteristic tripartite structure comprising an O-antigen, a core oligosaccharide, and lipid A. These lipopolysaccharides may contribute to bacterial immune evasion by inhibiting complement-mediated killing and suppressing host antimicrobial peptide secretion, thus helping bacteria evade immune defenses. Possessing high viscosity and serum resistance, they can potentially induce sepsis. Additionally, these lipopolysaccharides are utilized in the development of animal models for sepsis/septicemia.

Antimicrobial agent-32 (Compound 4g) is an antibacterial compound with significant efficacy against several bacteria, including Staphylococcus aureus, Bacillus subtilis, Bacillus cereus [MIC=1000 µg/mL], Klebsiella pneumonia, and methicillin-resistant Staphylococcus aureus [MRSA] [MIC=500 µg/mL], as well as Escherichia coli [MIC=250 µg/mL]. Additionally, Antimicrobial agent-32 exhibits anticancer activity by inhibiting the proliferation of MCF-7, HCT-116, and HepG-2 cells.

Poly(I:C):Kanamycin (1:1) sodium is a complex.Poly(I:C) is a synthetic double-stranded RNA analogue and a TLR3 and RIG-I/MDA5 agonist that enhances immunity and promotes apoptosis in cancer cells.Kanamycin is an antimicrobial agent that is effective against both Gram-negative and positive bacteria which is able to bind the 70S ribosomal subunit.