it-901

IT-901 is an orally active and potent NF-κB subunit c-Rel inhibitor with IC50 values for NF-κB and c-Rel binding to DNA of 0.1 µM and 3 µM, respectively. IT-901 is a naphthalene thiobarbiturate derivative with antitumor activity and is used for the prevention and treatment of human lymphoma and myeloma.

Talizumab (TNX 901) is a humanized IgG1 monoclonal antibody that specifically targets circulating immunoglobulin E (IgE). it binds to free IgE not already bound by the high-affinity IgE receptors (FcεRI) present on mast cells and basophils, which leads to the marked downregulation of these receptors and additionally inhibits allergen-specific T-cell activation by interfering with antigen processing and presentation activities.