human bisphosphonate farnesyl diphosphate synthase

BPH-1358 (NSC-50460) (NSC-50460) is a potent human farnesyl diphosphate synthase (FPPS) and undecaprenyl diphosphate synthase (UPPS) inhibitor. With IC50s of 1.8 μM and 110 nM, respectively. And it is active against S. aureus in vitro (MIC ~250 ng/mL)[1][2].

BPH-1358 (NSC50460) free base is a potent human undecaprenyl diphosphate synthase (UPPS) and farnesyl diphosphate synthase (FPPS) inhibitor (IC50s: 110 nM and 1.8 μM) and is active against S. aureus in vitro (MIC ~250 ng/mL).

Alendronate sodium is a nitrogen-containing bisphosphonate that inhibits bone resorption. Alendronate sodium interferes with the mevalonate pathway by inhibiting farnesyl-3-phosphate (FPP) synthase in osteoclasts, thereby blocking osteoclast activity and inducing their apoptosis. Sodium alendronate is used in the treatment of metabolic bone diseases such as osteoporosis and Paget’s disease of bone.