hm4

DREADD agonist 21 is a potent agonist of human muscarinic acetylcholine M3 receptors (EC50=1.7 nM).

HM43239 is an orally active and selective FLT3 inhibitor with IC 50 s of 1.1 nM, 1.8 nM and 1.0 nM for FLT3 WT, FLT3 internal tandem duplication (ITD) and FLT3 D835Y kinases, respectively. HM43239 directly inhibits the kinase activity of FLT3 as a reversible Type I inhibitor and effectively modulates downstream p-STAT5 and p-ERK. HM43239 also demonstrated inhibition of SYK, JAK1/2 and TAK1. HM43239 inhibits the proliferation and induces the apoptosis of leukemic cells [1] [2] [3].

Anti-Mouse CD48 Antibody (HM48-1) is an IgG antibody inhibitor derived from the American hamster, targeting mouse CD48.

VU6008055 is a potent, selective, orally bioavailable M4 positive allosteric modulator that can cross the blood-brain barrier. It exhibits EC50 values of 73.4 nM for hM4 and 19.5 nM for rM4, and it demonstrates antipsychotic-like activity.

VU6002703 (Compound 17) is a brain-penetrant positive allosteric modulator (PAM) of the M4 muscarinic acetylcholine receptor (mAChR), exhibiting an EC50 of 0.6 μM for hM4. This compound is useful for researching neuropsychiatric disorders and rare genetic central nervous system conditions.

VU6028418 is a highly selective, potent, orally active M4mAChR antagonist that acts on hM4 (IC50: 4.1 nM).

VU6008677 is a positive allosteric modulator (PAM) of M4 with an EC50 of 120 nM for hM4. It inhibits cytochrome P450 (cytochrome P450) and exhibits a high microsomal clearance rate and high plasma protein binding in rats.