hiv1 inhibitor6 

HIV-1 inhibitor-6 (3-Pyridinecarboxamide, 1,4-dihydro-1-methyl-N-(5-nitro-1,2-benzisothiazol-3-yl)-4-oxo-) is a potent HIV-1 pre-mRNA selective splicing inhibitor that blocks HIV replication.

HIV-1inhibitor-62 (Compound 6) is an HIV-1 inhibitor useful for antiviral research.

HIV-1inhibitor-63 (compound S17) is a potent inhibitor of HIV-1. It effectively suppresses the formation of the integrase-Ku70 complex with an IC50 value of 12 µM. Additionally, HIV-1inhibitor-63 impedes the post-integration DNA repair of HIV-1.

HIV-1inhibitor-65 (compound 3c) is an inhibitor of HIV-1 with an EC50 of 2.9 nM and serves as an activator of protein kinase C (PKC). It effectively hinders syncytium formation with an EC50 of 7.0 nM, and prevents HIV-1 entry as well as the action of HIV-1 reverse transcriptase.

HIV-1inhibitor-66 is an orally active non-nucleoside reverse transcriptase inhibitor (NNRTI) that exhibits inhibitory activity against wild-type HIV-1 reverse transcriptase (HIV-1 reverse transcriptase) with an IC50 of 40 nM.

HIV-1inhibitor-68 (compound 26) is a derivative that activates protein kinase C (PKC) and exhibits latency-reversing activity in HIV-1. It holds potential for eradicating cells latently infected with HIV-1.

HIV-1 Inhibitor-61 (2c) serves as a potent inhibitor of HIV-1 reverse transcriptase, exhibiting an EC50 value of 0.07 nM in NL4-3 wt MT-4 cells [1].

HIV-1 inhibitor-64 (Compound 7c) is an effective wild-type HIV-1 suppressant, also capable of inhibiting HIV-1 mutants E138K/Q148K and G140S/Q148R with EC50 values of 62.5 nM and 11.3 nM, respectively. This compound demonstrates antiviral activity and is applicable in AIDS research [1].