herbicidal

Glyphosate (Atila) is an herbicide. It also is a possible carcinogen to humans.

Herbicidal agent 6 (D15) functions as a Transketolase (TKL) inhibitor and exhibits herbicidal activity.

Herbicidal agent 8 (Compound 9w) targets auxin indole-3-acetic acid (IAA), disrupting the physiological activities of plant cells and ultimately causing plant death. Herbicidal agent 8 exhibits herbicidal activity against both broadleaf and grass weeds.

Herbicidal agent 7 (Compound 15c) acts as an inhibitor of protoporphyrinogen IX oxidase (PPO). By interfering with pigment synthesis in plants, it demonstrates herbicidal activity against broadleaf weeds such as Z. elegans and A. theophrasti, as well as grass weeds like S. glauca and E. crusgalli.

Herbicidal agent 10 (compound 3s) is a highly effective herbicide. It inhibits SvEPSPS with an IC50 value of 7.8 μM.

Herbicidal agent 4 (compound V-2) is an oxidative herbicide. It can upregulate defense genes and increase jasmonic acid levels, suggesting it may also function as an immune activator.

Herbicidal agent 3 (compound 7A) exhibits herbicidal activity against large crabgrass (Digitaria sanguinalis) and redroot pigweed (Amaranthus retroflexus) at a dosage of 90g ai/ha. It also inhibits the enzyme activity of green foxtail (Setaria viridis) TKL (SvTKL), with an IC50 value of 0.740 mg/L.

Herbicidal agent 1 ((S)-6q) exhibits superior activity compared to its racemic form [1].

Herbicidal Agent 9 (compound 5) is a derivative of 23-spirostane with herbicidal properties. When used in combination with compound 6, it inhibits the growth of Arabidopsis roots, exhibiting an EC50 value of 6.89 μM.

Imazapic (Imazamethapyr) has a broad herbicidal spectrum and controls a variety of annual grass weeds.

Quizalofop-ethyl (NC 302) is a aryloxyphenoxypropionate herbicide used for post-emergence control of annual and perennial grass weeds within broadleaf crops such as soybeans, cotton, and peanuts, and its herbicidal activity is mediated through the potent inhibition of the acetyl-CoA carboxylase (ACCase) enzyme.

PPO-IN-17 (Compound 6R) functions as an inhibitor of protoporphyrinogen IX oxidase (PPO), effectively inhibiting tobacco PPO (NtPPO) with a Ki of 30.34 nM. This compound demonstrates herbicidal activity, achieving an inhibition rate greater than 95% against E. crus-galli, D. sanguinalis, M. sativa, and C. canadensis at a concentration of 37.5 g/hm2. Additionally, PPO-IN-17 shows no toxicity to rice at 75 g/hm2 and to bees at 6400 mg/kg.

PPO-IN-16 (Compound D5) is a PPO inhibitor and herbicide with a Ki of 33.7 nM for tobacco PPO (NtPPO). It has a broad spectrum of herbicidal activity and exhibits good safety in crops such as wheat, rice, and peanuts.

Herbicide safener-4 (Compound I-15) is a herbicide safener designed to enhance crop resistance to herbicides without diminishing the herbicidal effects on target weeds. It competitively binds to the ALS active site alongside Mesosulfuron-methyl. In addition, Herbicide safener-4 boosts the activities of glutathione GSH, glutathione-S-transferase GST, cytochrome P450 CYP450, peroxidase (POD), superoxide dismutase (SOD), and acetolactate synthase (ALS) within plants.

PPO-IN-18 (Compound g13) is an inhibitor of protoporphyrinogen oxidase (PPO) and effectively inhibits Echinochloa crus-galli PPO (EcPPO) with an IC50 of 0.109 μM. It demonstrates herbicidal activity against E. crus-galli, Digitaria sanguinalis, Setaria faberi, Ipomoea nil, Chenopodium quinoa, and Abutilon theophrasti, with no significant crop toxicity at application rates of 150-300 g ai/ha.

NtPPO-IN-1 (Compound A4) is an inhibitor of Nicotiana tabacum PPO (NtPPO) with a Ki of 9.05 nM. It exhibits herbicidal activity against Setaria viridis, Echinochloa crus-galli, Digitaria sanguinalis, Amaranthus retroflexus, Abutilon theophrasti, and Portulaca oleracea, causing 30-50% damage to corn and rice at 150 g a.i./ha.

PPO-IN-19 (Compound 7m) is a protoporphyrinogen IX oxidase (PPO) inhibitor with an IC50 of 124 nM. It exhibits herbicidal activity and is relevant for herbicide-related research in the agricultural sector.

PPO-IN-20 (Compound B18) is a potent inhibitor of Protoporphyrinogen IX oxidase (PPO), with a Ki value of 10.3 nM for NtPPO. It exhibits broad-spectrum herbicidal activity, making it a valuable compound for agricultural research.

Transketolase-IN-5 (compound 6ba) is an inhibitor of transketolase. It exhibits herbicidal activity against Amaranthus retroflexus, Setaria viridis, and Digitaria sanguinalis.

PPO-IN-12 (Compound E-Ic) is an inhibitor of tobacco protoporphyrinogen IX oxidase (NtPPO) with a Ki of 3 nM. It possesses broad-spectrum herbicidal properties and demonstrates effective inhibitory activity against broadleaf weeds.

PPO-IN-13 (compound B16) is a potent inhibitor of protoporphyrinogen IX oxidase (PPO), with a Ki of 32.14 nM. At a concentration of 37.5 g a.i./ha, PPO-IN-13 demonstrates broad-spectrum and excellent herbicidal efficacy against Echinochloa crusgalli, Digitaria sanguinalis, Setaria faberii, Abutilon juncea, Amaranthus retroflexus, and Portulaca oleracea.

PPO-IN-11 (Compound 10bh) is an inhibitor of protoporphyrinogen IX oxidase (PPO) and specifically inhibits tobacco PPO (NtPPO) with a Ki of 0.0603 μM. It exhibits herbicidal activity against dicotyledonous weeds such as Leaf mustard, Chickweed, and Chenopodium serotinum, as well as monocotyledonous weeds like Alopecurus aequalis, Poa annua, and Polypogon fugax at a dosage of 150 g a.i./ha.

DHODH-IN-27 (WF-8) is an inhibitor of dihydroorotate dehydrogenase (DHODH) with an IC50 value of 64.97 μM. This compound is used as an herbicidal agent targeting DHODH.

Antifungalagent 134 (Compound B13) is an antifungal agent effective against Botrytis cinerea, Alternaria solani, Fusarium graminearum, Rhizoctonia solani, Colletotrichum orbiculare, and Alternaria alternata with EC50 values of 3.24, 1.89, 1.70, 0.36, 4.27, and 1.50 μg/mL, respectively. It disrupts the fungal cell membranes and mitochondria, leading to substantial accumulation of reactive oxygen species (ROS). Additionally, Antifungalagent 134 exhibits significant herbicidal activity on field weeds such as Amaranthus retroflexus L and Abutilon theophrasti Medicus, and is applicable in crop disease and field weed research.