heptapeptide

Acetyl sh-heptapeptide-1, a polypeptide, has demonstrated efficacy in combatting facial aging [1].

Acetyl heptapeptide-4, a bioactive peptide known for its antiallergic properties, is utilized as an ingredient in cosmetics [1].

Kemptide TFA is a synthetic heptapeptide, acting as a substrate for cAMP-dependent protein kinase (PK).

Alexamorelin Met 1 is one of the metabolites of alexamorelin. The heptapeptide Ala-His-D-2-methyl-Trp-Ala-Trp-D-Phe-Lys-NH2 (Alexamorelin) is a synthetic molecule which inhibits growth hormone secretagogue binding in vitro.

Dermorphin Analog, an analog of Dermorphin, is a natural heptapeptide μ-opioid receptor agonist found in amphibian skin. The dermorphin-derived peptide [Dmt1] Dermorphin Analog labels μ-opioid receptors with high affinity and selectivity in receptor binding assays.

Super-tdu (1-31) TFA is an endogenous ligand of heptapeptide receptor and has a strong anti-analgesic effect.

Eptifibatide (Eptifibatide Acetate), an antiplatelet drug of the glycoprotein IIb IIIa inhibitor class, is a cyclic heptapeptide constructed from 6 amino acids and a mercaptopropionyl residue.

PapRIV, a quorum-sensing heptapeptide derived from B. cereus, undergoes synthesis as a 48-amino acid polypeptide. This compound is secreted and then extracellularly processed by NprB proteases into its active form. At concentrations ranging from 1-25 µM, PapRIV triggers the production of IL-6 and TNF-α, as well as NF-κB translocation, specifically in BV-2 microglia cells.

Phalloidin, a bicyclic heptapeptide found in Gooseberry, is involved in F-actin staining. Phalloidin is a compound that irreversibly polymerizes actin into microfilaments.Phalloidin interferes with cell motility and growth, and can be used to label cerebral blood vessels.

Eptifibatide acetate (148031-34-9 free base) (Eptifibatide acetate) , an antiplatelet drug of the glycoprotein IIb IIIa inhibitor class, is a cyclic heptapeptide constructed from 6 amino acids and a mercaptopropionyl residue.

Unguisin B is a cyclic heptapeptide originally isolated from the marine fungus E. unguis whose structure is comprised of amino acids and GABA.

Lagatide is a synthetic heptapeptide that has antisecretory activity.

Substance P (5-11), the C-terminal heptapeptide derived from Substance P, functions as a neuropeptide that specifically interacts with the NK-1 tachykinin receptor [1].

Amyloid-Forming peptide GNNQQNY, a biologically active heptapeptide derived from the N-terminal prion-determining domain of yeast Sup35, is instrumental in amyloid fibril formation. Its atomic oligomeric structure has been detailed, serving as an excellent model for investigating early-stage aggregation. The peptide can form three stable β-sheet structures: in-register parallel, off-register parallel, and anti-parallel. Notably, the in-register parallel dimer aligns closely with amyloid β-sheet architecture, relying on fewer interpeptide hydrogen bonds and emphasizing hydrophobic interactions, which enhances conformational entropy relative to the anti-parallel arrangement.

LH-RH (4-10), a heptapeptide, represents one of the primary degradation products of luteinising-hormone releasing hormone (LHRH), occurring through the pathways of the pituitary and hypothalamus. It is produced in macrophages and type II pneumocytes [1].

Alamandine can be formed from angiotensin A by action of ACE-2 or directly from angiotensin-(1-7) by decarboxylation of its aspartate residue. The angiotensin A analog produces effects resembling those of Ang II (1-7). However, it acts independently of the two known vasodilators receptors of the RAS (Mas and angiotensin II type 2). To produce its effects, alamandine binds to the Mas-related receptor, MrgD. A novel orally active formulation of alamandine produced a long-term antihypertensive effect in spontaneously hypertensive rats and cardioprotective effects. These novel findings will be helpful for developing a new understanding of the RAS, a key regulator of blood pressure and fluid balance. The heptapeptide could serve as a model peptide, e.g. in the development and evaluation of analytical methods.

Dermorphin is agonist of μ-opioid receptor (MOR) agonist.

Angiotensin (1-7) (ASP-ARG-VAL-TYR-ILE-HIS-PRO) is a synthetic heptapeptide identical to endogenous angiotensin-(1-7) , inhibits purified canine ACE activity (IC50=0.65 μM) with vasodilator and antiproliferative activities.

Vaccarin C (Compound VIII) is a cyclic heptapeptide with significant antifungal activity, demonstrating a MIC of 6 µg mL against pathogenic fungi and dermatophytes M. audouinii and T. mentagrophytes. It also exhibits high cytotoxicity against Dalton's lymphoma ascites (DLA) and Ehrlich ascites carcinoma (EAC) cell lines, with CTC50 values of 3.35 and 5.72 μmol L, respectively.

Kemptide is a synthetic heptapeptide, acting as a substrate for cAMP-dependent protein kinase (PK).

Dermorphin TFA is a new class of opioids-like peptides

DTX-P7 is a peptide drug conjugate (PDC) composed of Docetaxel (DTX) and a heptapeptide (P7), which induces the unfolded protein response and subsequent apoptosis by degrading Hsp90.

AT1R epitope (iCF10) is a heptapeptide and acts as a competitive inhibitor of cCF10, a peptide pheromone.