hcn channels

Ivabradine hydrochloride (S 16257-2) is a new If inhibitor (IC50: 2.9 μM). Ivabradine Hydrochloride is the hydrochloride salt form of ivabradine, an orally bioavailable, hyperpolarization-activated, cyclic nucleotide-gated (HCN) channel blocker, with negative chronotropic activity. Upon administration, ivabradine selectively binds to the intracellular portion of the HCN channel pore and blocks HCN channels in the pacemaker cells within the sinoatrial (SA) node. This inhibits the If (funny) pacemaker ion current, prevents the inward flow and intracellular accumulation of positively charged ions, reduces pacemaker activity and slows diastolic depolarization.

ZD7288 (ICI D7288), a selective hyperpolarization-activated cyclic nucleotide-gated channel blocker, inhibits hippocampal synaptic plasticity.

Cilobradine hydrochloride (DK-AH 269) is an HCN Channel blocker and an open channel blocker of neuronal Ih and related cardiac If channels.

Zatebradine is a potent hyperpolarization-activated cyclic nucleotide-gated (HCN) channels inhibitor(IC50 of 1.96 µM).

Zatebradine hydrochloride (UL-FS-49CL) is a highly effective and effective HCN Channel inhibitor (IC50:1.96 µM). HCN Channel is an effective hyperpolarization activated loop nucleotide gated channel. Zatebradine hydrochloride blocks slow inward currents through human HCN1, HCN2, HCN3, and HCN4 channels with IC50 values of 1.83 µM, 2.21 µM, 1.90 µM, and 1.88 µM, respectively.

Cilobradine is an HCN Channel blocker; an open channel blocker of neuronal Ih and related cardiac If channels.

Ivabradine Impurity 2, an impurity of Ivabradine, is a compound known for its oral bioavailability and mechanism as a blocker of hyperpolarization-activated, cyclic nucleotide-gated (HCN) channels [1].

KIO-301 chloride, an azobenzene photoswitch compound, inhibits voltage-gated ion channels, such as hyperpolarisation-activated cyclic nucleotide-gated (HCN) channels and voltage-gated potassium channels, upon exposure to visible light [1].