h 151

H-151 is a highly potent and selective STING antagonist. H-151 covalently binds to Cys91 of STING and inhibits palmitoylation of Cys91, thereby inhibiting STING activity. H-151 can be used in the study of autoinflammatory diseases in vivo and ex vivo.

H-151 Alkyne (Compound H-151-AL) is a selective inhibitor of STING (stimulator of interferon genes). It shows promise for research in autoimmune diseases, including systemic lupus erythematosus, scleroderma, and autoinflammatory diseases.

LH1513 is a dioxalate salt derivative of l-lysine that inhibits CaOx crystallization more effectively than citrate and pyruvate. It shows potential preventive activity in hyperoxaluria models and effectively prevents urinary CaOx crystal formation in Agxt knockout mice. AGXT-1 is a mitochondrial protein involved in metabolic processes.

SJH1-51B is an effective PROTAC degrader of BRD4, exhibiting antitumor properties.

WZH-15-125 is a potent ALK inhibitor capable of overcoming resistance, particularly with complex ALK mutations. It exhibits an IC50 of 101.7 nM against the highly recalcitrant Lorlatinib-resistant G1202R/L1196M mutation. Additionally, WZH-15-125 can serve as a PROTAC target protein ligand for synthesizing PROTACWZH-17-002. This compound is applicable in non-small cell lung cancer research.

Trihydroxycholestanoic Acid is an endogenous metabolite found in the blood and an intermediate product in the biosynthesis of cholic acid. Abnormally elevated levels of Trihydroxycholestanoic Acid are associated with various peroxisome-related disorders, including Zellweger syndrome, Refsum disease, peroxisomal D-bifunctional protein deficiency, and infantile Refsum disease, and can be used to study the mechanisms underlying these metabolic disorders.

STING Agonist 1a is a specific STING agonist with interferon-inducing activity, offering potential applications in antiviral and antitumor research.

[Leu144,Arg147]-PLP (139-151) is a mutated fragment of the myelin proteolipid protein (PLP), featuring substitutions of tryptophan to leucine and histidine to arginine at positions 144 and 147, respectively. Immunizing mice with this peptide (50 µg) mixed in complete Freund's adjuvant (CFA) elevates IL-4 levels in the spleen. While it suppresses Th1 cell activation in vitro, it does not do so in vivo; instead, it promotes the development of regulatory T cells. Preimmunization with [Leu144, Arg147]-PLP (139-151) postpones the onset of experimental autoimmune encephalomyelitis (EAE) triggered by encephalitogenic peptides from PLP (178-191), myelin oligodendrocyte glycoprotein (MOG) (92-106), or myelin basic protein (MBP) in mice.