gpr81

GPR81 agonist 1 is a potent and selective GPR81 agonist with high affinity for human and mouse GPR81, inhibiting lipolysis of differentiated 3T3-L1 adipocytes, improving insulin sensitivity and glycaemic control in mouse models of insulin resistance and diabetes, and can be used in the study of diabetes and obesity.

3-chloro-5-hydroxy Benzoic Acid (3-chloro-5-hydroxy BA) is an agonist of GPR81 (EC50 : 16 μM)

GPR81 agonist 2 is a potent agonist targeting the GPR81 receptor, demonstrating EC50 values of 0.023 µM for hGPR81 and 0.123 µM for hGPR109A, respectively.

Lactic acid (2-hydroxypropanoic acid), a glycolysis end product, is a hydroxycarboxylic acid receptor 1 (HCAR1) activator (EC50=4.2-5 mM). Lactic acid can be used as a hemodynamic index in critically ill patients and has anti-tumor activity.