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By Target- Bcr-Abl
- Ligand for E3 Ligase(1)
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Results for "
gmb 475
" in TargetMol Product Catalog- Inhibitors & Agonists3
- PROTAC Products2
GMB-475 
T84882490599-18-1
GMB-475 is a BCR-ABL1 tyrosine kinase degrader based on PROTAC, overcoming BCR-ABL1-dependent drug resistance. GMB-475 targets BCR-ABL1 protein and recruits the E3 ligase Von Hippel Lindau (VHL).resulting in ubiquitination and subsequent degradation of th
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(S,R,S)-AHPC TFA
VH032-NH2 TFA, VHL ligand 1 TFA
T179271631137-51-3
(S,R,S)-AHPC TFA (VHL ligand 1 TFA) (VH032-NH2 TFA) is a VH032-based ligand designed for von Hippel-Lindau (VHL) protein recruitment. This compound can be linked to protein ligands (e.g., BCR-ABL1) using a linker to create PROTACs (e.g., GMB-475), which effectively induce the degradation of BCR-ABL1, demonstrated by an IC50 of 1.11 μM in Ba F3 cells.
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