glycosylase

OGG1-IN-08 (OGG1-IN-O8) is an inhibitor of 8-oxoguanine DNA glycosylase 1 (OGG1;IC50 : 0.35 μM)

SU0268 is a potent and specific 8-Oxoguanine DNA glycosylase 1 (OGG1) inhibitor that regulates inflammatory responses during Pseudomonas aeruginosa infection.

Human alkyl adenine DNA glycosylase is a monomeric DNA glycosylase that repairs various alkylated and deaminated nucleobases, helping to maintain genomic integrity.

TH1085 is an enhancer of OGG1. TH1085 stimulates DNA repair and protects cells from the environmental hazard paraquat (PQ).

TH5487 is an potent inhibitor of 8-oxoguanine DNA glycosylase 1 (OGG1)( IC50 of 342 nM)

MtUng-IN-1 (Compound 18a) inhibits mycobacterial uracil DNA glycosylase (MtUng) with an IC50 value of 300 μM and is suitable for cancer and infectious disease research.

TDG-IN-1 is an orally active, selective small molecule inhibitor of thymine DNA glycosylase (TDG) with a Ka of 1.46 nM. It disrupts TDG's DNA binding ability, induces downregulation of DHX9 expression, leads to double-stranded RNA accumulation, and activates the RIG-I/MDA5-MAVS pathway. Additionally, it acts as a tumor suppressor, innate immune activator, and immune stimulator. TDG-IN-1 inhibits the growth of p53-deficient tumor cells and xenografts, exhibiting a synthetic lethal effect with p53. This compound is useful for research in p53-deficient cancers.

T4EndonucleaseV is a bifunctional DNA glycosylase that exhibits both DNA N-glycosylase and AP lyase activities. It is capable of repairing cyclobutane pyrimidine dimers induced by ultraviolet (UV) radiation in DNA.

EndonucleaseVIII is a DNA repair enzyme capable of excising oxidized pyrimidines from DNA. As a bacterial DNA glycosylase/AP lyase, EndonucleaseVIII can remove modified pyrimidines, including thymine glycol (Tg), uracil glycol, dihydrothymine, and dihydrouracil (DHU).

β-Aspartyl-N-acetylglucosaminidase (EC 3.2.2.11) is part of the hydrolase family, specifically functioning as a glycosylase that hydrolyzes N-glycosyl compounds.