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  • GABA Receptor
    (13)
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Results for "

gabaa α5  receptor

" in TargetMol Product Catalog
  • Inhibitors & Agonists
    13
    TargetMol | Inhibitors_Agonists
DMCM hydrochloride
T110611215833-62-7In house
DMCM hydrochloride is a non-selective fully inverse agonist of benzodiazepine. DMCM showed significant differences in human recombinant GABAA αxβ3γ2 receptor subtypes. For α1, α2, α3, and α5 receptors, their Kis were 10 nM, 13 nM, 7.5 nM, 2.2 nM, respectively.
  • $31
In Stock
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α5-GABAA receptor modulator 1
T205217
α5-GABAA receptor modulator 1 (Compound A-4) is a selective silent allosteric modulator (SAM) targeting the α5 subunit of GABAA receptors, useful for research into central nervous system (CNS) disorders.
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CP-457920
CP457920
T31057220860-50-4
CP-457920 is a selective α 5 GABAA receptor agonist for the treatment of dementia in Alzheimer's disease.
  • $342
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MRK-016
MRK016
T12105342652-67-9
MRK-016 is a selective GABAA α5 receptor inverse agonist negative allosteric modulator, (IC50=3 nM) with the advantages of being orally available and penetrating the blood-brain barrier.MRK-016 increases long time period potentiation (LTP) in mouse hippocampal slices, with memory-improvement, antidepressant, and pain-treating effects.
  • $42
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L-838417
L838417, L 838417
T19702286456-42-6
L-838417 is a GABAA receptor subtype-selective benzodiazepine site-selective ligand and GABAA receptor-positive modulator.L-838417 is a selective partial agonist of the α2, α3, and α5 subtypes and an antagonist of the α1 subtype and is used in the study of anxiety disorders.
  • $51
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NS11394
NS 11394
T2067951650-22-9
NS11394 is a effective and subtype-selective GABA(A) receptor-positive modulator; possesses a functional efficacy selectivity profile of α(5) > α(3) > α(2) > α(1) at GABA(A) alpha subunit-containing receptors.
  • $29
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ENX-101
T206766
ENX-101 is an orally active partial positive allosteric modulator (PAM) of the (GABAA) receptor. It selectively targets the α2β2γ2L (EC50= 0.76 nM), α2β3γ2L (EC50= 0.61 nM), α3 (EC50= 1.97 nM), and α5 (EC50= 0.85 nM) subunits of the GABA receptor. ENX-101 demonstrates anticonvulsant activity in various animal models.
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L-822179
L822179, L-822,179, L822,179, L 822179, L 822,179
T24381215874-86-5
L-822179 (α5IA) is a selective inverse agonist for the Α5 subtype of GABAA receptor with higher intrinsic activity at the A5 subtype than other drugs.
  • $38
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ZK93423
ZK-93423,ZK 93423
T2922883910-44-5
ZK93423 is a potent agonist of benzodiazepine receptor (IC50 = 1 nM) with non-selective between α1-, α2-, α3- and α5-subunit containing GABAA receptors, Ki values are 4.1, 4.2, 6 and 4.5 nM for inhibition of [3H]Ro15-1788 binding to human recombinant α1β3
  • $1,520
6-8 weeks
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GABAA receptor modulator-2
T628852413850-54-9
GABAA receptor modulator-2 (Compound 20) is a selective, orally active α5-GABAAR negative conformation modulator (Ki: 4.1 nM) that exhibits high metabolic stability and a good central nervous system safety profile.
  • $2,140
6-8 weeks
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Basmisanil
RO5186582, RG1662
T71651159600-41-5
Basmisanil (RG1662) is a negative allosteric modulator/inverse agonist of GABAAα5 receptors.Formulations containing basmisanil are in clinical trials for the treatment of cognitive impairments associated with Down syndrome.
  • $32
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TargetMol | Inhibitor Sale
mrk-898
T86930461450-30-6
MRK-898, an orally active modulator of the GABA(A) receptor, selectively interacts with the α1, α2, α3, and α5 subunits, displaying K i values of 1.2 nM, 1.0 nM, 0.73 nM, and 0.50 nM, respectively. It is noteworthy that the α1-containing receptors of GABA(A) are classified as sedative, whereas receptors containing α2 and or α3 are designated as anxiolytic subtype(s) [1].
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10-14 weeks
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ONO-8590580
CS-2894
TQ00401802661-73-9
ONO-8590580 (CS-2894) is a negative allosteric modulator of GABAA α5.
  • $60
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