fludarabine phosphate

Fludarabine Phosphate (NSC 312887 Phosphate) is the phosphate salt of a fluorinated nucleotide antimetabolite analog of the antiviral agent vidarabine (ara-A) with antineoplastic activity. Fludarabine phosphate is rapidly dephosphorylated to 2-fluoro-ara-A and then phosphorylated intracellularly by deoxycytidine kinase to the active triphosphate, 2-fluoro-ara-ATP. This metabolite may inhibit DNA polymerase alpha, ribonucleotide reductase, and DNA primase, thereby interrupting DNA synthesis and inhibiting tumor cell growth.

3'-Beta-C-Methyl-N6-isopentenyl adenosine, an adenosine analog, primarily acts as a smooth muscle vasodilator and has shown potential in inhibiting cancer progression. Popular products in this category include adenosine phosphate, Acadesine, Clofarabine, Fludarabine phosphate, and Vidarabine [1].

2-Amino-3',5'-di-O-acetyl-N6,N6-dimethyl-2'-O-methyladenosine is an adenosine analog, known for primarily acting as a smooth muscle vasodilator and for inhibiting cancer progression. Its popular products include adenosine phosphate, Acadesine, Clofarabine, Fludarabine phosphate, and Vidarabine [1].

2'-O-Methyladenosine 5'-monophosphate triethyl ammonium is an adenosine analog that primarily functions as a smooth muscle vasodilator and has demonstrated potential in inhibiting cancer progression. Its notable products include adenosine phosphate, Acadesine, Clofarabine, Fludarabine phosphate, and Vidarabine [1].

Fludarabine triphosphate (F-ara-ATP), the cytotoxic metabolite of Fludarabine phosphate, inhibits ribonucleotide reductase and DNA polymerase, ultimately leading to cellular apoptosis.

3'-Beta-C-ethynyl-N6-(m-trifluoromethyl benzyl)adenosine is an adenosine analog. Adenosine analogs primarily act as smooth muscle vasodilators and have also demonstrated inhibition of cancer progression. Notable related compounds include adenosine phosphate, Acadesine, Clofarabine, Fludarabine phosphate, and Vidarabine [1].

1-(β-D-Xylofuranosyl)-N6-Isopentenyladenine is an adenosine analog that primarily functions as a smooth muscle vasodilator and has been shown to inhibit cancer progression. Notable products include adenosine phosphate, Acadesine, Clofarabine, Fludarabine phosphate, and Vidarabine [1].

1-(β-D-Xylofuranosyl)-N6-(m-trifluoromethylbenzyl)adenine is an adenosine analog that predominantly functions as a smooth muscle vasodilator and has been shown to inhibit cancer progression. Its notable products include adenosine phosphate, Acadesine, Clofarabine, Fludarabine phosphate, and Vidarabine [1].

1-(β-D-Xylofuranosyl)-N6-(m-methoxybenzyl)adenine is an adenosine analog, primarily acting as a smooth muscle vasodilator and inhibiting cancer progression. Popular products include adenosine phosphate, Acadesine, Clofarabine, Fludarabine phosphate, and Vidarabine [1].

2-Diethoxymethyl adenosine is an adenosine analog primarily acting as a smooth muscle vasodilator and inhibiting cancer progression. Notable products include adenosine phosphate, Acadesine, Clofarabine, Fludarabine phosphate, and Vidarabine [1].

3'-Beta-C-ethynyl-N6-iso-pentenyl adenosine is an adenosine analog that primarily functions as a smooth muscle vasodilator and has demonstrated potential in inhibiting cancer progression. Its notable derivatives include adenosine phosphate, Acadesine, Clofarabine, Fludarabine phosphate, and Vidarabine [1].