flavivirus

HeE1-2Tyr, a pyridobenzothiazole compound, is a potent inhibitor of flavivirus RNA-dependent RNA polymerases (RdRp). It significantly inhibits the RdRp activity of West Nile, Dengue, and SARS-CoV-2 in vitro, with an IC50 of 27.6 µM.

Flaviviruses-IN-2 is a potent flaviviruses inhibitor. Flaviviruses-IN-2 reduces West Nile virus (WNV) protease activity and inhibits WNV by 56%.

Flaviviruses-IN-3 (compound 87) is a potent inhibitor of flaviviruses, capable of reducing West Nile virus (WNV) protease activity by 54%.

Flaviviruses-Inhibitor-I is several viruses belonging to the family of Flaviviridae inhibitor.

1. Palmatine (Burasaine) is an inhibitor of dopamine generation. 2. Palmatine could potentially be developed for the treatment of flavivirus infections. 3. Palmatine has been used in the treatment of jaundice, dysentery, hypertension, inflammation, and liver-related diseases.

NSC-323241 is a potent inhibitor of STT3A-mediated mega protein complex assembly. It disrupts the large endoplasmic reticulum (ER) complexes localized by STT3A during dengue virus (DENV) and Zika virus (ZIKV) infections. NSC-323241 interferes with the binding of the STT3A subcomplex to viral non-structural proteins (such as NS2B, NS3) and host transporter proteins, thus impairing the formation of the viral replication microenvironment. This compound holds promise for researching flavivirus infections, including dengue and Zika viruses.

DENV-IN-13 (Compound 30) is an inhibitor of DENV2 protease with an EC50 of 9.8 μM in HeLa cells. It exhibits potent antiviral activity with minimal cytotoxicity and does not inhibit off-target enzymes such as thrombin and trypsin. DENV-IN-13 is applicable in flavivirus infection research.

KIN1148 is a novel small-molecule adjuvant that acts through the RIG-I pathway and IRF-3 transcription factor to stimulate inN/Ate immunity and protection following viral infection. The adjuvant will be developed for an FDA-approved avian inluenza virus v

NS2B/NS3-IN-3 (Compd 66) is a Flavivirus NS2B-NS3 protease inhibitor [1].

ToP-DNJ is a selective inhibitor of endoplasmic reticulum α-Glucosidase II and exhibits antiflaviviral activity. ToP-DNJ is relevant for investigations involving viral glycoprotein maturation, endoplasmic reticulum-associated protein processing, and flavivirus-host interaction mechanisms.

NITD-203 is a flavivirus inhibitor.

NSC 288387, a pan-flavivirus MTase inhibitor, binds to the SAM-binding pocket and effectively inhibits Zika virus (ZIKV) with an IC50 of 0.2 μM, also preventing viral replication in cell culture [1].

NS2B/NS3-IN-3 hydrochloride is a Flavivirus NS2B-NS3 protease inhibitor [1].

Glabranine is a natural prenylated flavonoid isolated from Tephrosia species that exhibits potent inhibitory activity against the Dengue virus (DENV) in vitro. Its primary mechanism involves interacting with the soluble ectodomain of the DENV type 2 (DENV2) Envelope (E protein), potentially blocking viral entry or membrane fusion. The presence of the prenyl group is considered essential for its biological potency, making it a valuable scaffold for flavivirus-targeted drug discovery.