Shopping Cart
  • Remove All
  • TargetMol
    Your shopping cart is currently empty
Filter
Applied FilterClear all
TargetMol | Tags By Target
  • Dehydrogenase
    (12)
  • DNA/RNA Synthesis
    (3)
  • Apoptosis
    (1)
  • Parasite
    (1)
  • Others
    (9)
Filter
Search Result
Results for "

dhodh-in-1

" in TargetMol Product Catalog
  • Inhibitors & Agonists
    26
    TargetMol | Inhibitors_Agonists
  • Recombinant Protein
    1
    TargetMol | Recombinant_Protein
DHODH-IN-1
T110191800296-63-2In house
DHODH-IN-1 is a potent dihydroorotate dehydrogenase (DHODH) inhibitor with IC50 of 25 nM. DHODH-IN-1 is an inhibitor of the pyrimidine biosynthetic pathway.
  • Inquiry Price
6-8 weeks
Size
QTY
TargetMol | Inhibitor Sale
RORγt/DHODH-IN-1
T641452764662-15-7
RORγt DHODH-IN-1 (compound (R)-14d) is a potent, orally active dual inhibitor of RORγt (IC50: 0.083 μM) and DHODH (IC50: 0.172 μM), exhibiting significant in vivo anti-inflammatory effects.
  • Inquiry Price
10-14 weeks
Size
QTY
DHODH-IN-12
T110211263303-93-0In house
DHODH-IN-12 is a leflunomide derivative and a weak dihydrorotate dehydrogenase (DHODH) inhibitor with a pKa of 5.07.
  • Inquiry Price
6-8 weeks
Size
QTY
DHODH-IN-13
T110221364791-86-5In house
DHODH-IN-13 is an inhibitor of DHODH with IC50 of 4.3 μM for rat liver. DHODH-IN-13 can be used in studies about rheumatoid arthritis.
  • Inquiry Price
6-8 weeks
Size
QTY
TargetMol | Inhibitor Sale
DHODH-IN-14
T110231364791-93-4In house
DHODH-IN-14 is an analog of hydroxyfuran pyrimidine A771726. DHODH-IN-14 is a dihydroorotate dehydrogenase (DHODH) inhibitor IC50 0.49 μM mouse liver DHODH. DHODH-IN-14 can be used for rheumatoid arthritis.
  • Inquiry Price
8-10 weeks
Size
QTY
TargetMol | Inhibitor Sale
DHODH-IN-15
T110241364791-88-7In house
DHODH-IN-15 is the hydroxyfuran analogue of A771726. DHODH-IN-15 is a dihydroorotate dehydrogenase (DHODH) inhibitor with an IC50 of 11 μM for rat liver DHODH. DHODH-IN-15 can be used for rheumatoid arthritis.
  • Inquiry Price
6-8 weeks
Size
QTY
TargetMol | Inhibitor Sale
DHODH-IN-17
T6036416344-26-6In house
DHODH-IN-17 is a human DHODH inhibitor with an IC50 of 0.40 μM. DHODH-IN-17 is a 2- anilino nicotinic acid that can be used in the study of acute myeloid leukemia (AML).
  • Inquiry Price
6-8 weeks
Size
QTY
hDHODH-IN-1
T115461173715-42-8
hDHODH-IN-1 is a human dihydroorotate dehydrogenase (hDHODH) inhibitor exhibiting anti-inflammatory properties.
  • Inquiry Price
6-8 weeks
Size
QTY
TargetMol | Inhibitor Sale
DHODH-IN-11
T110201263303-95-2
DHODH-IN-11 is a leflunomide derivative and weak dihydroorotate dehydrogenase (DHODH) inhibitor with a pKa of 5.03.
  • Inquiry Price
Size
QTY
TargetMol | Inhibitor Sale
PfDHODH-IN-1
T12438183945-55-3
PfDHODH-IN-1, an analogue of the active Leflunomide metabolite, exhibits antimalarial activity.
  • Inquiry Price
Size
QTY
TargetMol | Inhibitor Sale
hDHODH-IN-12
T78932
hDHODH-IN-12 is a potent inhibitor of dihydroorotate dehydrogenase (DHODH), exhibiting an inhibitory concentration (IC50) of 0.421 μM. As the rate-limiting enzyme in the de novo synthesis of pyrimidines, critical for DNA RNA synthesis, DHODH is localized within the inner membrane of human mitochondria. hDHODH-IN-12 is applicable in lung cancer research [1].
  • Inquiry Price
Size
QTY
hDHODH-IN-16
T203173
hDHODH-IN-16 (Compound 3t) is an inhibitor of human dihydroorotate dehydrogenase (hDHODH) with an IC50 of 0.11 μM. It demonstrates very low cytotoxicity towards healthy HaCaT cells, with an IC50 value exceeding 200 μM.
  • Inquiry Price
Size
QTY
DHODH-IN-16
T401682511248-11-4
DHODH-IN-16 is an effective inhibitor of dihydroorotate dehydrogenase (DHODH, IC50 = 0.396 nM for human).
  • Inquiry Price
Size
QTY
DHODH-IN-18
T403092685799-97-5
DHODH-IN-18 is a human DHODH inhibitor with an IC50 value of 0.2 nM.
  • Inquiry Price
Size
QTY
hDHODH-IN-10
T63037
hDHODH-IN-10 is a selective, orally active, potent hDHODH inhibitor (IC50: 10.9 nM) that forms hydrogen bonds with key residues Arg136 and Gln47. It inhibits cancer cell proliferation and can be used to study cancers (e.g. AML, colon cancer).
  • Inquiry Price
10-14 weeks
Size
QTY
DHODH-IN-19
T636522742675-85-8
DHODH-IN-19, a potent inhibitor of DHODH, has demonstrated research potential for cancer and inflammatory diseases.
  • Inquiry Price
6-8 weeks
Size
QTY
hDHODH-IN-11
T729482396653-34-0
hDHODH-IN-11, a potent inhibitor of human dihydroorotate dehydrogenase (hDHODH), exhibits an IC50 value of 7.2 nM and has low cytotoxicity. It is applicable in acute myeloid leukemia (AML) research.
  • Inquiry Price
6-8 weeks
Size
QTY
hDHODH-IN-13
T822233032611-13-2
hDHODH-IN-13 (compound w2), an inhibitor of human dihydroorotate dehydrogenase (hDHODH), exhibits an IC50 of 173.4 nM and has potential research applications in studying inflammatory bowel disease (IBD) [1].
  • Inquiry Price
Size
QTY
hDHODH-IN-14
T86564881826-17-1
Compound 14 (hDHODH-IN-14) is an inhibitor of human dihydroorotate dehydrogenase (hDHODH), exhibiting an IC50 value of 0.469 μM [1].
  • Inquiry Price
4-6 weeks
Size
QTY
hDHODH-IN-15
T88973
hDHODH-IN-15 (Compound H19) acts as an inhibitor of human dihydroorotate dehydrogenase (hDHODH), demonstrating an IC50 of 0.21 µM. It exhibits cytotoxic effects in cancer cells such as NCI-H226, HCT-116, and MDA-MB-231, with IC50 values ranging from 0.95 to 2.81 µM. Furthermore, hDHODH-IN-15 induces ferroptosis in HCT-116 cells and shows antitumor activity.
  • Inquiry Price
Size
QTY
CHIKV-IN-2
T93942361289-44-1
CHIKV-IN-2, a chemical compound, exhibits potent inhibitory activity against the enzyme Dihydroorotate Dehydrogenase (DHODH), crucial for pyrimidine synthesis affecting various viruses' replication. It serves as an effective Chikungunya virus (CHIKV) inhibitor, demonstrating significant cellular antiviral activity (EC90=270 nM) and enhanced liver microsomal stability[1].
  • Inquiry Price
Size
QTY
TargetMol | Inhibitor Sale
Farudodstat
ASLAN003
T103841035688-66-4
Farudodstat (ASLAN003) is an orally active and potent inhibitor of DHODH (Human Dihydroorotate Dehydrogenase) with antitumor activity, showing potential as a first-in-class candidate in AML [Acute Myeloid Leukemia].
  • Inquiry Price
Size
QTY
RORγt/DHODH-IN-2
T624622641758-86-1
RORγt DHODH-IN-2 (compound 1) is a potent dual inhibitor of RORγt and DHODH, useful for studying inflammatory bowel disease (IBD).
  • Inquiry Price
6-8 weeks
Size
QTY
RORγt/DHODH-IN-3
T64146
RORγt DHODH-IN-3 (compound (S)-14d) is a potent, orally active dual inhibitor of RORγt (IC50: 0.098 μM) and DHODH (IC50: 0.432 μM) with significant in vivo anti-inflammatory effects.
  • Inquiry Price
10-14 weeks
Size
QTY