death associated protein kinase

3MB-PP1 is a bulky purine analog and a Polo-like kinase 1 (Plk1) inhibitor. In cells expressing analog-sensitive Plk1 alleles, 3MB-PP1 blocks mitotic progression and cell division arise by targeting Plk1. 3MB-PP1 specifically inhibits analog-sensitive Ssn3 (Cdk8). 3MB-PP1 inhibits Leu93 Mutant Zipper-interacting protein kinase with IC50 of 2 μM. 3MB-PP1 can be used for the research of cell division and hypha formation of Candida albicans.

TC-DAPK 6 is an ATP-competitive inhibitor of Death-associated protein kinase (DAPK) with IC50s of 69 and 225 nM for DAPK1 and DAPK3.

DAPK1-IN-1 (compound 10) is an inhibitor of Death-associated protein kinase 1 (DAPK1), with a dissociation constant (Kd) of 0.63 μM. It is utilized in the study of Alzheimer's disease.

CK156 is a potent inhibitor of death-associated protein kinase (DAPK), demonstrating high selectivity. In the DRAK1 NanoBRET assay, CK156 exhibits IC50 values of 182 nM, 34 μM, and 39 μM for DRAK1, CK2a1, and CK2a2, respectively. This compound is valuable for studying autoimmune and inflammatory diseases [1].

DAPK Substrate Peptide TFA is a synthetic peptide used as a substrate for the enzyme death-associated protein kinase (DAPK), with a Michaelis constant (Km) of 9 μM [1].

HS148 is a selective inhibitor of DAPK3 (death-associated protein kinase 3), with a Ki value of 119 nM. Inhibition of DAPK3 by HS148 has been shown to reduce the progression of gastric cancer by activating the ULK1-dependent pathway, which is implicated in cellular autophagy and tumor suppression mechanisms.

TAT-GluN2BCTM is a membrane-permeable peptide that selectively targets active DAPK1 (Death-associated protein kinase 1) for lysosomal degradation, protecting neurons against oxidative stress and NMDAR-mediated excitotoxicity, making it valuable for neuroprotection research studies [1].

Necroptosis-IN-5 (Compound 26) is an orally active inhibitor of necroptotic cell death (necroptosis). This compound also exhibits potent inhibitory activity against receptor-interacting protein kinase 1 (RIPK1). It can be utilized in research related to inflammatory diseases, neurodegenerative disorders, and cancer associated with necroptosis.

DAPK Substrate Peptide is a synthetic peptide substrate for death-associated protein kinase (DAPK) [Km = 9 μM].

DAPK Substrate Peptide acetate is a death-associated protein kinase (DAPK, Km = 9 μM) peptide substrate.