deacetylated

1. Ganoderic acid D is one of the major components in Ganoderma triterpenes. 2. Ganoderic acid D treatment for 48h inhibits the proliferation of HeLa human cervical carcinoma cells with an IC(5) value of 17.3 +/- .3 microM.

Norgestimate is an acetylated progestinused in combination with ethinyl estradiol as an oral contraceptive.

N-deacetylated BMS-202 is an inhibitor of PD-1/PD-L1 interactions and has potential anticancer activity for cancer research.

Chitosan (Deacetylated chitin) (≥95% deacetylated, viscosity 100-200 mPa.s) is a polysaccharide derived from the deacetylation of chitin, which exhibits antimicrobial activity against various bacteria and fungi.

Chitosan hydrochloride 80%-90% deacetylated (Chitosan HCl 80%-90% deacetylated) is the hydrochloride salt form of chitosan. This polysaccharide, produced through the deacetylation of chitin, exhibits antibacterial activity against various bacteria and fungi. It is utilized in agriculture, water treatment, and pharmaceuticals.

Chitosan (Deacetylated chitin) (≥90% deacetylated, viscosity 10 mPa.s) is a polysaccharide derived from the deacetylation of chitin and exhibits antimicrobial activity against various bacteria and fungi. Chitosan (≥90% deacetylated, viscosity 10 mPa.s) serves as a versatile biomaterial, applicable in drug delivery, tissue engineering, and wound healing.

Chitosan (≥80% deacetylated, Medium viscosity,200-400mPa.s) is a biochemical reagent that can be used as a biomaterial for life science related research and as a sulfonylation reagent for organic synthesis and drug discovery.

Chitosan (≥80% deacetylated, High viscosity,>400mPa.s) is a biochemical reagent that can be used as a biomaterial for life science related research and as a sulfonylation reagent for organic synthesis and drug discovery.

Chitosan (≥85% deacetylated, viscosity>90 mPa.s, MW 15000) is a reagent used in biochemical reactions.

Chitosan (MW 150000) (Deacetylated chitin) is a linear polysaccharide made up of randomly distributed β-(1-4)-linked D-glucosamine (deacetylated unit) and N-acetyl-D-glucosamine.

Uridine triacetate (RG 2133 triacetate) (Tri-O-acetyl uridine), an orally active prodrug of uridine, is efficiently absorbed in the gut and swiftly deacetylated in the circulation to release free uridine. It is utilized in the research of 5-fluorouracil (5-FU) and capecitabine toxicity, particularly targeting early-onset cardiac or central nervous system (CNS) complications.

Gitoxigenin is the deacetylated homolog of oleandrin, which is a natural product with specific biochemical activity.

HT-2 Toxin, a deacetylated metabolite of T-2 toxin, impairs protein synthesis and hinders cell proliferation in plants.

1-β-D-Glucosylsphingadienine is a glucosylsphingosine, which are deacetylated lysolipid derivatives of glucosylcerebrosides . They are formed when sphingosines undergo glucosidation by UDP-glucose. Glucosylsphingosines completely reduce neurite outgrowth and induce death of LA-N-2 cells at concentrations of 10 and 50 μM, respectively. They also decrease the activity of glucocerebrosidase in LA-N-2 cells in a dose-dependent manner. Glucosylsphingosine levels are elevated in patients with Gaucher's disease, both in the spleen (in types 1, 2, and 3) and brain (type 2 and 3); thus, glucosylsphingosine has been used as a key biomarker of the disease. This product contains 1-β-D-glucosylsphingadienine isolated from plants.

GSK1790627, the N-deacetylated metabolite of Trametinib, represents an orally active MEK inhibitor that promotes autophagy and triggers apoptosis [1].

Ganoderic acid T1, a deacetylated derivative of Ganoderic acid T, diminishes mitochondrial membrane potential and triggers cell apoptosis by activating caspase-9 and caspase-3, thus impairing the antioxidant defense system of cancer cells. Additionally, it elevates intracellular ROS levels, yielding pro-oxidant activities and cytotoxicity [1].

Deacetylescin Ia (compound 12) is an anti-hyperglycemic deacetylated saponin extracted from de-bittered Ginkgo biloba leaves by deacetylation at position C-22. In mice glucose tolerance tests, Deacetylescin Ia (100mg kg) demonstrated an ability to inhibit the increase in blood sugar levels.