cystathionine γ-lyase

Cystathionine-γ-lyase-IN-1 (SHIP-2a) is a selective inhibitor of cystathionine γ-lyase (CSE) enzyme (IC50= 6.3 μM).

DL-Propargylglycine HCl (DL-Propargyl Glycine HCl) is a potent irreversible inhibitor of cystathionine γ-cleaving enzyme and can be used in the study of heart failure.

Cystathionine γ-lyase is a biocatalyst and a key enzyme in new biocatalyst technology. Enzyme engineering focuses on improving enzymatic reaction kinetics, substrate selectivity, and activity under harsh conditions (e.g., low or high pH). By introducing stimulus responsiveness through modifications, dynamic control of activity also becomes possible.

I194496 is an effective inhibitor of cystathionine γ-lyase (CSE) with an IC50 value of 0.79 mM. It inhibits the growth of human TNBC cells by dual targeting the PI3K/Akt and Ras/Raf/ERK pathways. Additionally, I194496 suppresses the metastasis of human TNBC cells by downregulating the Anxa2/STAT3 and VEGF/FAK/Paxillin signaling pathways.

NL3 is an inhibitor of bacterial cystathionine gamma-lyase, exhibiting IC50 values of 0.7 μM for [bCSE] and 3.4 μM for [hCSE]. It is applicable in research focused on antibacterial activity and overcoming bacterial resistance.

bCSE-IN-1 (Compound 3i) is an inhibitor of bacterial cystathionine γ-lyase (bacterial cystathionine γ-lyase) and exhibits antibacterial activity. bCSE-IN-1 (Compound 3i) is utilized in antimicrobial research focused on bacterial sulfur metabolism, enzymatic pathway disruption, and mechanistic studies of cystathionine γ-lyase-dependent microbial viability.

3,5,7,8,4'-Pentamethoxyflavone is a Ca2+ channel inhibitor. 3,5,7,8,4'-Pentamethoxyflavone can protect DNA from oxidative damage. 3,5,7,8,4'-Pentamethoxyflavone can induce relaxation of the human corpus cavernosum through calcium mobilization-related mechanisms. 3,5,7,8,4'-Pentamethoxyflavone can promote the expression of eNOS and cystathionine gamma lyase CSE proteins in middle-aged male rats and regulate vascular function. 3,5,7,8,4'-Pentamethoxyflavone can be used in research related to diabetes and cardiovascular diseases. 3,5,7,8,4'-Pentamethoxyflavone is additionally applicable in vascular biology and metabolic research systems for investigating calcium channel–mediated signaling regulation, endothelial function modulation, and oxidative stress–associated vascular response mechanisms in cellular and animal experimental models.