cyp2a

β-Tetralone (2-Tetralone) is an essential chemical constituent employed as a pivotal precursor in the intricate manufacturing process of medicinal drugs and diverse organic substances.

(2-methylpropyl)({[3-(trifluoromethyl)phenyl]methyl})amine is a selective serotonin receptor agonist that specifically targets 5-HT2A and 5-HT2C receptors. It has been used to study the role of serotonin in a variety of physiologic and pathologic conditions.

Pilocarpine Hydrochloride (NSC 5746 HCl) is an M3-type muscarinic acetylcholine receptor agonist. Pilocarpine Hydrochloride is used to generate experimental models of epilepsy.

Clomethiazole (Distraneurin) is an orally active GABAA agonist and it is an anticonvulsant agent. It also has the potential for treating convulsive status epilepticus. Chlormethiazole inhibits cytochrome P450 isoforms: CYP2A6 and CYP2E1 in human liver microsomes.

Gentiopicroside (Gentiopicrin), a naturally occurring iridoid glycoside, extracted from Gentiana manshurica Kitag, inhibits P450 activity, with an IC50 and a Ki of 61 μM and 22.8 μM for CYP2A6; has antianti-inflammatoryand antioxidative effects.

Ginsenoside C-K (Ginsenoside K) is a bacterial metabolite of G-Rb1 exhibiting anti-inflammatory effects by reducing iNOS and COX-2.

ε-Viniferin (epsilon-Viniferin) a dimer of resveratrol, shows the inhibitory effects of epsilon-viniferin on human CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2B6, CYP2E1, CYP3A4 and CYP4A activities.

3-Phenylthiophene (Compound 25) is a CYP2A6 inhibitor with a Ki of 3.3 μM. It exhibits Ki values of 9.7, 14, 112, and 107 μM for CYP2E1, CYP2B6, CYP2C9, and CYP2C19, respectively, and shows no significant inhibition of CYP3A4 and CYP2D6. 3-Phenylthiophene is applicable for smoking cessation research.

2-Phenyl-2-(1-piperidinyl)propane (PPP), an analog of phencyclidine, is a chemical compound.

Chalepensin, a furanocoumarin isolated from the rutaceae plant Ruta chalepensis L., is a selective CYP2A6 inhibitor, inhibiting CYP1A1, CYP1A2, CYP2A13, CYP2C9, CYP2D6, CYP2E1, and CYP3A4.Chalepensin exhibits Chalepensin j has antiprotozoal activity and inhibits methicillin-resistant Staphylococcus aureus (MRSA) with MIC values in the range of 32-128 μg/mL.

DL-Acetylshikonin can effectively inhibit tumor cells, it can be used to treat hepatocellular carcinoma cells expressing hepatitis B virus X protein (HBX) by inducing ER stress , an oncoprotein from hepatitis B virus. Acetylshikonin inhibits the production of eicosanoid, is due to the attenuation of cytosolic phospholipase A(2) membrane recruitment via the decrease in [Ca(2+)](i) and to the blockade of cyclooxygenase and 5-lipoxygenase activity.

Indole-2-carboxaldehyde is a classic synthetic intermediate for indole heterocycles and can be used in the synthesis of indole alkaloids, pharmaceutical molecules, pesticides, fluorescent probes, and other compounds. Indole-2-carboxaldehyde inhibits hCYP2A6, with an IC₅₀ value of 1.8 μM.