cm-10

CM10 is an aldehyde dehydrogenase 1A family(ALDH1A) inhibitor.

CM-10-18 is a potent inhibitor of ER α-glucosidase, demonstrating superior in vitro antiviral activity against representative viruses from four viral families causing hemorrhagic fever, and efficiently protecting against the lethality of dengue virus infection in mice.

UCM-1306 is a potent and orally active allosteric modulator (PAM) of the human dopamine D1 receptor. It increases the maximal effect of endogenous dopamine (DA) in both human and mouse D1 receptors. UCM-1306 could improve motor symptoms and address key comorbid cognitive impairment associated with long-term Parkinson's disease (PD).

CM101 is an anti-pathogenic angiogenic polysaccharide derived from Group B Streptococcus. It inhibits inflammatory angiogenesis, accelerates wound healing in mouse models, and reduces scar formation post-spinal cord injury. Additionally, CM101 rapidly induces tumor neovascular inflammation, promotes inflammatory cell infiltration, suppresses tumor growth, and induces tumor apoptosis (apoptosis).

Nebokitug is a humanized IgG1κ antibody targeting CCL24, with HumanIgG1kappa, Isotype Control serving as its corresponding isotype control.

PF-06273340 is an effective, Selective, and Peripherally Restricted Pan-Trk inhibitor (IC50: Trk-A = 6 nM; Trk-B = 4 nM; Trk-C = 3 nM). PF-06273340 has low metabolic turnover in HLM and hHep is a good substrate for efflux transporters P-gp (ER = 35.7) and BCRP (ER = 4.0) and has moderate passive permeability (RRCK Papp = 5.4 × 10 6 cm s 1).

Antibiofilm agent-8 (compound Ru2) boosts antibacterial activity under visible light (400-700 nm, 10 J cm-2). It induces oxidative stress by promoting NADH oxidation and reactive oxygen species (ROS) generation, which disrupts the bacterial cell wall.

GSK3β-IN-3 is an ATP-competitive GSK-3β inhibitor (IC50= 0.90 μM) that demonstrates good blood-brain barrier permeability (Pe= 10.7 x 10^-6 cm/s). It effectively reduces tau protein phosphorylation in the BR5706 strain and decreases Aβ aggregate deposition in the CL2006 strain, indicating its potential as a candidate for Alzheimer's disease (AD) research.

Ensartinib (X-396) is a potent and orally active dual ALK/MET inhibitor for the treatment of ALK-positive non-small cell lung cancer (NSCLC).

Nitroso-PSAP is a precise chromogenic reagent utilized for detecting iron (Fe 2+ ) through colorimetric analysis of blood samples post-mineralization with periodic acid. It forms a green complex with iron (Fe 2+ ), characterized by a maximum wavelength (λmax) of 756 nm and an Epsilon value of 4.5 x 10⁴ dm³ mol^-1 cm^-1 [1] [2].