cm-10

CM-10-18 is a potent inhibitor of ER α-glucosidase, demonstrating superior in vitro antiviral activity against representative viruses from four viral families causing hemorrhagic fever, and efficiently protecting against the lethality of dengue virus infection in mice.

CM10 is an aldehyde dehydrogenase 1A family(ALDH1A) inhibitor.

PF-06273340 is an effective, Selective, and Peripherally Restricted Pan-Trk inhibitor (IC50: Trk-A = 6 nM; Trk-B = 4 nM; Trk-C = 3 nM). PF-06273340 has low metabolic turnover in HLM and hHep is a good substrate for efflux transporters P-gp (ER = 35.7) and BCRP (ER = 4.0) and has moderate passive permeability (RRCK Papp = 5.4 × 10 6 cm s 1).

Ensartinib (X-396) is a potent and orally active dual ALK MET inhibitor for the treatment of ALK-positive non-small cell lung cancer (NSCLC).