cidea

trans-Chalcone (Chalkone) is an aromatic ketone that forms the central core for a variety of important biological compounds, which are known collectively as chalcones.

N-Acetylneuraminic acid (Acide aceneuramique) is a nine-carbon sialic acid monosaccharide commonly found in glycoproteins on cell membranes and in glycolipids such as gangliosides in mammalian cells. Studies have shown that N-Acetylneuraminic acid is biologically useful for neurotransmission, leukocyte extravasation, viral or bacterial infections, and carbohydrate-protein recognition.

(Rac)-Golgicide A ((Rac)-GCA) is a racemate of Golgicide A, used in the synthesis of Golgicide A.

Golgicide A-1 (GCA-1) is a moderately potent cis-diastereomer variant of Golgicide A (GCA), designed specifically to inhibit mosquito reproduction.

Golgicide A-2 (GCA-2), a derivative of Golgicide A (GCA), is the highly active enantiomer of GCA. It exhibits exceptional selectivity and efficiency in eradicating An. stephensi larvae, making it valuable for dengue virus-related research.

Golgicide A is a potent and rapidly reversible GBF1 inhibitor.

Rediocide A, an insecticide, can inhibit calcium mobilization in Drosophila G-protein- coupled receptors (GPCR)s other than methuselah, it can induce GPCR desensitization and internalization, and such effects are mediated by the activation of conventional

TH301 acts as a stabilizer for cryptochrome circadian regulator 2 (CRY2). It demonstrates selectivity by stabilizing CRY2 over CRY1 in a degradation assay conducted with HEK293 cells expressing CRY reporters at concentrations ranging from 0.1 to 10 µM. In wild-type mouse fibroblasts, TH301 extends the circadian period, but this effect is absent in Cry2-/- fibroblasts. Additionally, it boosts rosiglitazone-dependent induction of brown adipose tissue-specific genes such as Ucp1, Cidea, and Kcnk3 in primary mouse stromal vascular fractions.

3-Aminoisobutyric acid, a non-protein amino acid resultant from thymine catabolism, plays a significant role in metabolic activities. At a 5 µM concentration, it triggers browning in primary adipocytes, notably elevating uncoupling protein 1 (UCP-1) and CIDEA expression. Additionally, it boosts PPARα expression in both primary adipocytes and mouse inguinal white adipose tissue (WAT) in vivo, alongside enhancing β-oxidation in hepatocytes. Its plasma levels surge post-exercise in mice, and its administration at 100 mg/kg daily curtails weight gain and body fat without diminishing food consumption or hiking energy output, whilst ameliorating glucose tolerance. Notably, 3-aminoisobutyric acid concentrations are heightened in individuals with β-ureidopropionase deficiency, a genetic flaw impairing pyrimidine degradation, affecting plasma, urine, and cerebrospinal fluid.