chip

YL-109, a novel anticancer agent, can inhibit breast Y cell growth and invasiveness in vitro and in vivo.

CHIPOpt is a peptide and an orthosteric inhibitor of the CHIP TPR domain, with a dissociation constant (Kd) of approximately 16 nM. It exhibits anti-aggregation properties and reduces p.tau ubiquitination, while having minimal impact on unmodified tau protein. CHIPOpt is applicable in Alzheimer's disease research.

Hsp70-derived octapeptide acetate (Hsp70-derived octapeptide acetate) is a group of tetratricopeptide repeat (TPR)-containing proteins has been shown to interact with the C-terminal domain of the 70 kDa heat-shock cognate protein (hsc70). In the present study, the effect of the TPR-containing proteins, including the C-terminus of hsc70-interacting protein (CHIP), TPR1 and human glutamine-rich TPR-containing protein (hSGT), on refolding of luciferase by DnaJ and hsc70 was investigated.

Diptoindonesin G is an ERß stabilizer that regulates the stability of ERα and ERß by targeting CHIP E3 ubiquitin ligase. Diptoindonesin G could significantly increase the protein stability of ERß, and reduce the protein level of ERα,

Iproplatin is a synthetic second-generation platinum-containing compound related to cisplatin. Iproplatin binds to and forms DNA crosslinks and platinum-DNA adducts, resulting in DNA replication failure and cell death. Although less prone to glutathione i

Isonanangenine B is a drimane sesquiterpene lactone that has been found in Aspergillus. It decreases survivin mRNA expression in a reporter assay when used at concentrations of 13.6, 18.42, and 26.31 µM. Isonanagenine B (18.42 µM) inhibits STAT3 and NF-κB binding to the survivin promoter in chromatin immunoprecipitation (ChIP) assays. It also induces apoptosis in COLO 320DM cells.

FUBP1-IN-2 is a potent inhibitor of far upstream binding protein 1 (FUBP1), effectively disrupting the FUBP1-FUSE interaction in the KH4 domain as demonstrated in a gel shift assay. This compound also exhibits binding affinity to FUBP1 in ChIP assays. Furthermore, FUBP1-IN-2 significantly downregulates c-Myc mRNA and protein levels, upregulates p21 mRNA and protein levels, and depletes intracellular polyamines.

WBC100 (14-D-Valine-TPL) is a potent, selective, orally active c-Myc glue degrader targeting the ubiquitin E3 ligase CHIP-mediated 26S proteasome pathway, primarily used in research for c-Myc overexpressing tumors [1].

A group of tetratricopeptide repeat (TPR)-containing proteins has been shown to interact with the C-terminal domain of the 70 kDa heat-shock cognate protein (hsc70). In the present study, the effect of the TPR-containing proteins, including the C-terminus

Glycerophosphate disodium hydrate is a biochemical reagent used in chromatin immunoprecipitation assays. Glycerophosphate disodium hydrate has been employed in a novel microplate-based ChIP method to precipitate DNA-protein complexes from rat mesangial cells in a 96-well format, offering improved throughput and reproducibility for epigenetic research.