cdk2-in-24

CDK2-IN-24 (compound 3f) is an inhibitor of cyclin-dependent kinase 2, characterized by enhanced binding energy.

CGP74514A is a highly selective cyclin-dependent kinase 1 (CDK1) inhibitor with an IC50 of 25 nM. It effectively inhibits the activity of the CDK1/cyclin B complex, arrests the cell cycle at G2/M phase, and further induces apoptosis in tumor cells, showing promising application prospects in bladder cancer research.

NUAK1-IN-2 (Compound 24) is an inhibitor of NUAK1 with an IC50 of 3.162 nM, as well as an inhibitor of CDK2/4/6. It is applicable in research related to cancer, neurodevelopmental disorders, and Alzheimer's disease.

(R)-CDK2 degrader 6 (Compound 7) is the R enantiomer of CDK2 degrader 6. It functions as a selective molecular glue degrader for CDK2, with a DC50 of 27.0 nM within 24 hours. This compound can be utilized in breast cancer research.

(S)-CDK2 degrader 6 (Compound 8) is the S-enantiomer of CDK2 degrader 6. This selective CDK2 molecular glue degrader has a DC50 of 166.7 nM within 24 hours and is applicable in breast cancer research.

CDK-IN-9 (compound 24) is a potent inhibitor of CDK and acts on CDK2/E (IC50: 4 nM). It functions as a molecular gel that induces interaction between CDK12 and DDB1, and can dephosphorylate retinoblastoma protein and RNA polymerase II, thereby inducing apoptosis.

CPS2, a first-in-class, highly potent, selective, and irreversible PROTAC CDK2 degrader (IC 50 = 24 nM), is utilized in the research of acute myeloid leukemia [1].